External and internal exposure to the antigen in the hand eczema of nickel allergy

External and internal exposure to the antigen in the hand eczema of nickel allergy A provocation study was performed in twelve female patients with contact allergy to nickel and hand eczema of the pompholyx type. Intense handling of nickel‐contaminated metal objects did not induce any visible eczematous activity. Oral administration of nickel in a double‐blind test provoked an aggravation of the hand eczema in nine of the twelve patients, and in seven of the patients this was accompanied by secondary eruptions including outbreaks of earlier, healed eczema. The nickel dose given is probably in the upper limit of the presently known daily intake of the metal, but should be considered to be within the physiologic range. It is concluded that ingestion of small amounts of nickel may be of greater importance in maintaining the hand eczema than external contacts with the metal. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Contact Dermatitis Wiley

External and internal exposure to the antigen in the hand eczema of nickel allergy

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Publisher
Wiley
Copyright
Copyright © 1975 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0105-1873
eISSN
1600-0536
DOI
10.1111/j.1600-0536.1975.tb05354.x
Publisher site
See Article on Publisher Site

Abstract

A provocation study was performed in twelve female patients with contact allergy to nickel and hand eczema of the pompholyx type. Intense handling of nickel‐contaminated metal objects did not induce any visible eczematous activity. Oral administration of nickel in a double‐blind test provoked an aggravation of the hand eczema in nine of the twelve patients, and in seven of the patients this was accompanied by secondary eruptions including outbreaks of earlier, healed eczema. The nickel dose given is probably in the upper limit of the presently known daily intake of the metal, but should be considered to be within the physiologic range. It is concluded that ingestion of small amounts of nickel may be of greater importance in maintaining the hand eczema than external contacts with the metal.

Journal

Contact DermatitisWiley

Published: Jun 1, 1975

References

  • Atomic absorption spectrometry of nickel, copper, zinc, and lead in sweat collected from healthy subjects during sauna bathing
    Hohnadel, Hohnadel; Sunderman, Sunderman; Nechay, Nechay; McNeely, McNeely

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