Extent of lymph node dissection improves survival in prostate cancer patients treated with radical prostatectomy without lymph node invasion

Extent of lymph node dissection improves survival in prostate cancer patients treated with... INTRODUCTIONPelvic lymph node dissection (PLND) represents an integral part of comprehensive radical prostatectomy (RP) in patients with intermediate‐ or high‐risk prostate cancer (PCa) characteristics. PLND is indeed recommended in such patients according to North American and European guidelines. Despite its pivotal role in PCa staging, its therapeutic value is under debate.For example, Joslyn et al., as well as, Abdollah et al. and Moschini et al. showed decreased cancer‐specific mortality (CSM) in historical PCa patients treated with more extensive PLND at RP. However, others did not confirm this association. The same relationship between PLND extent and CSM was also shown in historical patients without lymph node invasion (LNI). However, again, it was disputed by others.These observations suggest the possibility of a beneficial effect of PLND extent on CSM, regardless of LNI status. This effect was described in other solid tumor primaries, including gastric, bladder, and colorectal cancers, where more extensive lymph node dissection (LND) improves CSM. As a consequence, lymph node count targets at LND represent a quality of care indicator in several solid primary tumors, including bladder, colorectal, and gastric cancer.Based on the importance of the concept, that more extensive LND may improve CSM, we tested this relationship in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Prostate Wiley

Extent of lymph node dissection improves survival in prostate cancer patients treated with radical prostatectomy without lymph node invasion

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0270-4137
eISSN
1097-0045
D.O.I.
10.1002/pros.23491
Publisher site
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Abstract

INTRODUCTIONPelvic lymph node dissection (PLND) represents an integral part of comprehensive radical prostatectomy (RP) in patients with intermediate‐ or high‐risk prostate cancer (PCa) characteristics. PLND is indeed recommended in such patients according to North American and European guidelines. Despite its pivotal role in PCa staging, its therapeutic value is under debate.For example, Joslyn et al., as well as, Abdollah et al. and Moschini et al. showed decreased cancer‐specific mortality (CSM) in historical PCa patients treated with more extensive PLND at RP. However, others did not confirm this association. The same relationship between PLND extent and CSM was also shown in historical patients without lymph node invasion (LNI). However, again, it was disputed by others.These observations suggest the possibility of a beneficial effect of PLND extent on CSM, regardless of LNI status. This effect was described in other solid tumor primaries, including gastric, bladder, and colorectal cancers, where more extensive lymph node dissection (LND) improves CSM. As a consequence, lymph node count targets at LND represent a quality of care indicator in several solid primary tumors, including bladder, colorectal, and gastric cancer.Based on the importance of the concept, that more extensive LND may improve CSM, we tested this relationship in

Journal

The ProstateWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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