Extent of lymph node dissection improves survival in prostate cancer patients treated with radical prostatectomy without lymph node invasion

Extent of lymph node dissection improves survival in prostate cancer patients treated with... INTRODUCTIONPelvic lymph node dissection (PLND) represents an integral part of comprehensive radical prostatectomy (RP) in patients with intermediate‐ or high‐risk prostate cancer (PCa) characteristics. PLND is indeed recommended in such patients according to North American and European guidelines. Despite its pivotal role in PCa staging, its therapeutic value is under debate.For example, Joslyn et al., as well as, Abdollah et al. and Moschini et al. showed decreased cancer‐specific mortality (CSM) in historical PCa patients treated with more extensive PLND at RP. However, others did not confirm this association. The same relationship between PLND extent and CSM was also shown in historical patients without lymph node invasion (LNI). However, again, it was disputed by others.These observations suggest the possibility of a beneficial effect of PLND extent on CSM, regardless of LNI status. This effect was described in other solid tumor primaries, including gastric, bladder, and colorectal cancers, where more extensive lymph node dissection (LND) improves CSM. As a consequence, lymph node count targets at LND represent a quality of care indicator in several solid primary tumors, including bladder, colorectal, and gastric cancer.Based on the importance of the concept, that more extensive LND may improve CSM, we tested this relationship in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Prostate Wiley

Extent of lymph node dissection improves survival in prostate cancer patients treated with radical prostatectomy without lymph node invasion

Loading next page...
 
/lp/wiley/extent-of-lymph-node-dissection-improves-survival-in-prostate-cancer-jPdq5bsJOa
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0270-4137
eISSN
1097-0045
D.O.I.
10.1002/pros.23491
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONPelvic lymph node dissection (PLND) represents an integral part of comprehensive radical prostatectomy (RP) in patients with intermediate‐ or high‐risk prostate cancer (PCa) characteristics. PLND is indeed recommended in such patients according to North American and European guidelines. Despite its pivotal role in PCa staging, its therapeutic value is under debate.For example, Joslyn et al., as well as, Abdollah et al. and Moschini et al. showed decreased cancer‐specific mortality (CSM) in historical PCa patients treated with more extensive PLND at RP. However, others did not confirm this association. The same relationship between PLND extent and CSM was also shown in historical patients without lymph node invasion (LNI). However, again, it was disputed by others.These observations suggest the possibility of a beneficial effect of PLND extent on CSM, regardless of LNI status. This effect was described in other solid tumor primaries, including gastric, bladder, and colorectal cancers, where more extensive lymph node dissection (LND) improves CSM. As a consequence, lymph node count targets at LND represent a quality of care indicator in several solid primary tumors, including bladder, colorectal, and gastric cancer.Based on the importance of the concept, that more extensive LND may improve CSM, we tested this relationship in

Journal

The ProstateWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from Google Scholar, PubMed
Create lists to organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off