Expression of slit‐2 and slit‐3 during chick development

Expression of slit‐2 and slit‐3 during chick development The Drosophila and vertebrate slit proteins have been characterized as secreted chemorepellents recognized by the robo receptor proteins that function principally for the guidance of neuronal axons and neurons. slit genes are also expressed in the limb. To provide a basis for the determination of slit functions in the limb we have isolated and characterized the expression of chick slit‐2 and slit‐3 in the developing limb and other tissues of the chick embryo. Both genes share similar expression profiles in the chick embryo when compared to that of their mammalian homologues, particularly in the neural tube. In the limb, their expression patterns suggest their involvement in many aspects of limb development. In the early limb bud, slit‐2 is expressed in the peripheral mesenchyme and invading muscle precursors, while slit‐3 expression is restricted to the future chondrogenic core of the limb bud. At later stages, both slit genes are expressed in interdigital mesenchyme, in inner periosteal cells, and in mesenchyme immediately radial to the periosteum and under the epidermis. slit‐3 is also expressed in proliferating chondrocytes during cartilage development, while slit‐2 is expressed in later muscle masses and peripherally to joints in the autopod. © 2001 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Developmental Dynamics Wiley

Expression of slit‐2 and slit‐3 during chick development

Developmental Dynamics, Volume 222 (2) – Oct 1, 2001

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Publisher
Wiley
Copyright
Copyright © 2001 Wiley‐Liss, Inc.
ISSN
1058-8388
eISSN
1097-0177
DOI
10.1002/dvdy.1182
Publisher site
See Article on Publisher Site

Abstract

The Drosophila and vertebrate slit proteins have been characterized as secreted chemorepellents recognized by the robo receptor proteins that function principally for the guidance of neuronal axons and neurons. slit genes are also expressed in the limb. To provide a basis for the determination of slit functions in the limb we have isolated and characterized the expression of chick slit‐2 and slit‐3 in the developing limb and other tissues of the chick embryo. Both genes share similar expression profiles in the chick embryo when compared to that of their mammalian homologues, particularly in the neural tube. In the limb, their expression patterns suggest their involvement in many aspects of limb development. In the early limb bud, slit‐2 is expressed in the peripheral mesenchyme and invading muscle precursors, while slit‐3 expression is restricted to the future chondrogenic core of the limb bud. At later stages, both slit genes are expressed in interdigital mesenchyme, in inner periosteal cells, and in mesenchyme immediately radial to the periosteum and under the epidermis. slit‐3 is also expressed in proliferating chondrocytes during cartilage development, while slit‐2 is expressed in later muscle masses and peripherally to joints in the autopod. © 2001 Wiley‐Liss, Inc.

Journal

Developmental DynamicsWiley

Published: Oct 1, 2001

References

  • Identification of high‐molecular‐weight proteins with multiple EGF‐like motifs by motif‐trap screening
    Nakayama, Nakayama; Nakajima, Nakajima; Nagase, Nagase; Nomura, Nomura; Seki, Seki; Ohara, Ohara
  • Characterization and developmental expression of Pax9, a paired‐box‐ containing gene related to Pax1
    Neubuser, Neubuser; Koseki, Koseki; Balling, Balling
  • Overexpression of a Slit Homologue Impairs Convergent Extension of the Mesoderm and Causes Cyclopia in Embryonic Zebrafish
    Yeo, Yeo; Little, Little; Yamada, Yamada; Miyashita, Miyashita; Halloran, Halloran; Kuwada, Kuwada; Huh, Huh; Okamoto, Okamoto
  • The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance
    Yuan, Yuan; Zhou, Zhou; Chen, Chen; Wu, Wu; Rao, Rao; Ornitz, Ornitz

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