Experimental 6 log 10 white cell‐reduction filters for red cells

Experimental 6 log 10 white cell‐reduction filters for red cells White cell (WBC) reduction of blood components has been receiving increased attention as a way of reducing transfusion‐related complications such as WBC‐associated HLA alloimmunization and transmission of cell‐associated viral diseases. Currently available filters are limited to removing approximately 3 log10 (99.9%) of WBCs from red cells (RBCs). The performance of two experimental filters that were designed to remove 6 log10 WBCs from fresh RBCs during component preparation was evaluated. Both filters were able to meet this objective in less than 40 minutes with RBC losses of < 15 percent under nonoptimized conditions. Filtered RBCs showed storage parameters within the normal range over a 42‐day period. The use of these filters, if combined with a sterile docking device or if incorporated into a collection set, should provide the means to supply highly WBC‐reduced RBCs with a normal shelf life. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transfusion Wiley

Experimental 6 log 10 white cell‐reduction filters for red cells

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Publisher
Wiley
Copyright
1992 AABB
ISSN
0041-1132
eISSN
1537-2995
D.O.I.
10.1046/j.1537-2995.1992.32292180140.x
Publisher site
See Article on Publisher Site

Abstract

White cell (WBC) reduction of blood components has been receiving increased attention as a way of reducing transfusion‐related complications such as WBC‐associated HLA alloimmunization and transmission of cell‐associated viral diseases. Currently available filters are limited to removing approximately 3 log10 (99.9%) of WBCs from red cells (RBCs). The performance of two experimental filters that were designed to remove 6 log10 WBCs from fresh RBCs during component preparation was evaluated. Both filters were able to meet this objective in less than 40 minutes with RBC losses of < 15 percent under nonoptimized conditions. Filtered RBCs showed storage parameters within the normal range over a 42‐day period. The use of these filters, if combined with a sterile docking device or if incorporated into a collection set, should provide the means to supply highly WBC‐reduced RBCs with a normal shelf life.

Journal

TransfusionWiley

Published: Feb 1, 1992

References

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