Expectations about the effectiveness of pain‐ and itch‐relieving medication administered via different routes

Expectations about the effectiveness of pain‐ and itch‐relieving medication administered via... IntroductionPlacebos have repeatedly been found to relieve pain and other symptoms, presumably through expectancies (Kirsch, ; Benedetti, ; Peerdeman et al., ). Not all placebos affect pain equally. An important treatment characteristic that has been associated with differential placebo effects on pain is the route of medication administration. It is frequently suggested that more invasive routes of medication administration (such as injections) lead to enhanced placebo effects (Lasagna, ; Kaptchuk et al., ; Schwartz et al., ). Indeed, placebo injections have been found to be more effective for relieving pain than oral placebos (de Craen et al., ; Zhang et al., ; Bannuru et al., ; Peerdeman et al., ). However, many research findings, looking also into other routes, are mixed regarding the possible enhanced effectiveness of more invasive routes for relieving pain (Macedo et al., ; Meissner et al., ; Bannuru et al., ; Fassler et al., ), while one study did not show substantial differences between different routes at all (Schwartz et al., ). Since differential placebo effects have important implications for clinical trials and clinical practice, further research into the underlying expectations about the effectiveness of medication administered via different routes is required.For further research, several factors should be considered. First, most previous research compared the placebo control http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pain Wiley

Expectations about the effectiveness of pain‐ and itch‐relieving medication administered via different routes

Loading next page...
 
/lp/wiley/expectations-about-the-effectiveness-of-pain-and-itch-relieving-3Res7phqdV
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 European Pain Federation ‐ EFIC®
ISSN
1090-3801
eISSN
1532-2149
D.O.I.
10.1002/ejp.1163
Publisher site
See Article on Publisher Site

Abstract

IntroductionPlacebos have repeatedly been found to relieve pain and other symptoms, presumably through expectancies (Kirsch, ; Benedetti, ; Peerdeman et al., ). Not all placebos affect pain equally. An important treatment characteristic that has been associated with differential placebo effects on pain is the route of medication administration. It is frequently suggested that more invasive routes of medication administration (such as injections) lead to enhanced placebo effects (Lasagna, ; Kaptchuk et al., ; Schwartz et al., ). Indeed, placebo injections have been found to be more effective for relieving pain than oral placebos (de Craen et al., ; Zhang et al., ; Bannuru et al., ; Peerdeman et al., ). However, many research findings, looking also into other routes, are mixed regarding the possible enhanced effectiveness of more invasive routes for relieving pain (Macedo et al., ; Meissner et al., ; Bannuru et al., ; Fassler et al., ), while one study did not show substantial differences between different routes at all (Schwartz et al., ). Since differential placebo effects have important implications for clinical trials and clinical practice, further research into the underlying expectations about the effectiveness of medication administered via different routes is required.For further research, several factors should be considered. First, most previous research compared the placebo control

Journal

European Journal of PainWiley

Published: Jan 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from
Google Scholar,
PubMed
Create lists to
organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off