Abbreviations6MWD6‐min walk distance6MWT6‐min walk testDLCOdiffusion capacity of the lung for carbon monoxideFEV1forced expiratory volume in 1 sFVCforced vital capacityILDinterstitial lung diseasePFTpulmonary function testRVresidual volumeSpO2oxygen saturationTLCtotal lung capacityINTRODUCTIONInterstitial lung disease (ILD) is a diverse group of entities that cause damage to the lung parenchyma through varying degrees of inflammation and fibrosis. Fibrotic ILDs result in restrictive ventilatory physiology and impaired gas exchange, frequently leading to exertional hypoxemia and functional limitation. The clinical and prognostic importance of exertional hypoxemia is well established, with multiple studies demonstrating a strong correlation of exertional desaturation with dyspnoea and mortality. Despite its importance, few studies have evaluated the severity, predictors and management of exertional oxygen desaturation in fibrotic ILD.Chronic obstructive pulmonary disease (COPD) is a common condition typically caused by cigarette smoking that results in a chronic inflammatory response involving the airways and lung parenchyma. COPD is characterized by persistent and progressive airflow limitation as well as impaired gas exchange that leads to dyspnoea and functional limitation. Despite similar features of dyspnoea and functional limitation in both ILD and COPD, the extent of exertional hypoxemia is often profound in patients with advanced ILD and may be more severe than in COPD. The objectives of this
Respirology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera