Excitotoxicity can be mediated through an interaction within the optic nerve; activation of cell body NMDA receptors is not required

Excitotoxicity can be mediated through an interaction within the optic nerve; activation of cell... Axonal trauma leads to a series of pathologic events that can culminate in neuronal death. Although the precise mechanisms of retinal ganglion cell death after optic nerve crush in the rat model have not been elucidated, glutamate antagonists can protect retinal ganglion cells after optic nerve axotomy. We therefore explored whether a glutamate congener was toxic if applied directly within the optic nerve, or if toxicity depended upon an interaction at the cell body level. NMDA reduced retinal ganglion cell survival when applied directly into the rat optic nerve. Glutamate can be toxic if administered within the optic nerve; a direct effect at the cell body is not necessary. Future work will help to additionally unravel the steps by which axotomy induces excitotoxic damage to ganglion cells, and perhaps indicate protective interventions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Veterinary Ophthalmology Wiley

Excitotoxicity can be mediated through an interaction within the optic nerve; activation of cell body NMDA receptors is not required

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Publisher
Wiley
Copyright
Copyright © 2001 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1463-5216
eISSN
1463-5224
D.O.I.
10.1046/j.1463-5216.2001.00168.x
Publisher site
See Article on Publisher Site

Abstract

Axonal trauma leads to a series of pathologic events that can culminate in neuronal death. Although the precise mechanisms of retinal ganglion cell death after optic nerve crush in the rat model have not been elucidated, glutamate antagonists can protect retinal ganglion cells after optic nerve axotomy. We therefore explored whether a glutamate congener was toxic if applied directly within the optic nerve, or if toxicity depended upon an interaction at the cell body level. NMDA reduced retinal ganglion cell survival when applied directly into the rat optic nerve. Glutamate can be toxic if administered within the optic nerve; a direct effect at the cell body is not necessary. Future work will help to additionally unravel the steps by which axotomy induces excitotoxic damage to ganglion cells, and perhaps indicate protective interventions.

Journal

Veterinary OphthalmologyWiley

Published: Sep 1, 2001

References

  • Recovery of brightness discrimination in adult rats despite progressive loss of retrogradely labeled retinal ganglion cells after controlled optic nerve crush
    Sautter, Sautter; Sabel, Sabel

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