1 A two‐compartment exploratory test was used to assess the role of central 5‐hydroxytryptaminergic neurones in the anxiolytic activity of buspirone in rats. 2 Buspirone 0.1 mg kg−1, administered subcutaneously 15 min before testing, significantly increased black‐white transitions (BWT) in control rats but had no effect in animals injected intra‐cerebroventricularly one week before with 150 μg 5,7‐dihydroxytryptamine (in 20 μl). 3 Infusion of buspirone in the median raphe (but not in the dorsal raphe) significantly enhanced BWT, at doses from 1 μg to 10 μg (in 0.5 μl). Buspirone 5 and 10 μg, but not 1 μg, administered in the median raphe, significantly enhanced motor activity of rats during the first 10 min of testing in the activity cages. 4 The effect on BWT of 5 μg buspirone in the median raphe was completely antagonized in animals which had received either 5,7‐dihydroxytryptamine intraventricularly, 150 μg (in 20 μl), one week before or an infusion of 0.1 μg (in 0.5 μl) (−)‐propranolol in the same area 5 min before. (−)‐Propranolol infused in the median raphe did not modify the effect of buspirone on locomotion. 5 Infusion of 5 μg buspirone (in 0.5 μl) in the median raphe significantly enhanced punished responses in a conflict test with no effect on unpunished responding. Buspirone infused in the dorsal raphe had no effect on punished or unpunished responding over a wide dose range. 6 The results indicate that at the relatively low dose used in the present study buspirone produces an anxiolytic effect by acting on central 5‐hydroxytryptaminergic neurones. It is likely that activation of 5‐hydroxytryptamine1A‐receptors in the median raphe is involved.
British Journal of Pharmacology – Wiley
Published: Apr 1, 1989
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