Evidence for vascular and enzymatic events in the pathophysiology of acute laminitis: which pathway is responsible for initiation of this process in horses? R. M. MOORE*, S. C. EADES and A. M. STOKES Equine Health Studies Program, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, USA. Keywords: horse; laminitis; vascular; haemodynamic Introduction Development of acute laminitis in horses often occurs secondary to other primary diseases; therefore, the mechanisms involved in the pathogenesis of laminitis are probably numerous and interrelated. Currently, there are 3 main theories regarding pathogenesis, but there are probably multiple factors within each theory that are involved. The 2 most popular theories regarding initiation of the acute laminitic cascade include those of vascular/haemodynamic and toxic/metabolic/enzymatic mechanisms. The third theory involves traumatic/mechanical factors associated with forces acting on the dermo-epidermal junction of the hoof/bone interface during weightbearing, exercise and other types of loading. Although it is unlikely these forces alone would be the initiating event, other than in those horses with overload laminitis that develops because the contralateral limb is nonweight bearing, these forces may contribute to the propagation of laminitis once initiated by one or other of the
Equine Veterinary Journal – Wiley
Published: Jan 1, 2004
Keywords: ; ; ;
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