Evidence for eosinophil activation in cow's milk allergy

Evidence for eosinophil activation in cow's milk allergy To assist in identifying pathogenetic mechanisms in different clinical manifestations of cow's milk allergy (CMA), the involvement of eosinophil cells in immunoinflammatory reactions was evaluated. The study population comprised 28 patients, aged from 5.8 to 43.0 months, who had challenge‐proven CMA, manifested either cutaneously (n = 17) or gastrointestinally (n = 11). A clinical cow's milk challenge was performed in hospital after a 4 week cow's milk elimination period. Eosinophil activation in vivo was studied by measuring the serum level of eosinophil cationic protein (ECP) before the oral cow's milk challenge, mean (SD) 27 (12) hours after commencing the challenge and one week later. These results were compared to those of 80 non‐allergic age‐matched controls. During the challenge, the level of ECP increased from 6.2 (4.5, 8.0) μg/L to 20.0 (9.5, 30, 4) μg/L in CMA patients with skin manifestations but not in those with gastrointestinal symptoms. The increase was shown to be transient. We conclude that eosinophil degranulation is an important immunologic mechanism leading to allergic inflammation in cutaneously manifested CMA. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Evidence for eosinophil activation in cow's milk allergy

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Publisher
Wiley
Copyright
Copyright © 1994 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/j.1399-3038.1994.tb00215.x
Publisher site
See Article on Publisher Site

Abstract

To assist in identifying pathogenetic mechanisms in different clinical manifestations of cow's milk allergy (CMA), the involvement of eosinophil cells in immunoinflammatory reactions was evaluated. The study population comprised 28 patients, aged from 5.8 to 43.0 months, who had challenge‐proven CMA, manifested either cutaneously (n = 17) or gastrointestinally (n = 11). A clinical cow's milk challenge was performed in hospital after a 4 week cow's milk elimination period. Eosinophil activation in vivo was studied by measuring the serum level of eosinophil cationic protein (ECP) before the oral cow's milk challenge, mean (SD) 27 (12) hours after commencing the challenge and one week later. These results were compared to those of 80 non‐allergic age‐matched controls. During the challenge, the level of ECP increased from 6.2 (4.5, 8.0) μg/L to 20.0 (9.5, 30, 4) μg/L in CMA patients with skin manifestations but not in those with gastrointestinal symptoms. The increase was shown to be transient. We conclude that eosinophil degranulation is an important immunologic mechanism leading to allergic inflammation in cutaneously manifested CMA.

Journal

Pediatric Allergy and ImmunologyWiley

Published: Feb 1, 1994

References

  • The immunobiology of eosinophils
    Weller, Weller
  • Variations of cationic proteins from eosinophil leukocytes in food intolerance and allergic rhinitis
    Winqvist, Winqvist; Olsson, Olsson; Werner, Werner; Stenstam, Stenstam

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