Evaluation of the use of recombinant human basic fibroblast growth factor in combination with negative pressure wound therapy with instillation and dwell time in porcine full‐thickness wound model

Evaluation of the use of recombinant human basic fibroblast growth factor in combination with... NPWT with instillation and dwell time (NPWTi‐d), which combines NPWT with wound irrigation, has been clinically applied as a more effective treatment than conventional NPWT. Commercially available recombinant human basic fibroblast growth factor (rh‐bFGF) has been demonstrated to be beneficial for use over the wound beds. The objective of this study was to evaluate the effectiveness of combined treatment with NPWTi‐d and rh‐bFGF. Six pigs received 12 full‐thickness excisional skin wounds and were treated with six different treatment groups for each pair. The treatment regimens were composed NPWTi‐d, NPWT, or advanced wound care with or without rh‐bFGF. On day 6, the minimum granulation tissue thickness and blood vessel number of the group of combined treatment with NPWTi‐d and rh‐bFGF spray were significantly greater than that of the control group. Combined treatment with NPWTi‐d and rh‐bFGF spray reads to good granulation tissue formation and vascularization for accelerating wound healing. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Wound Repair and Regeneration Wiley

Evaluation of the use of recombinant human basic fibroblast growth factor in combination with negative pressure wound therapy with instillation and dwell time in porcine full‐thickness wound model

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Publisher
Wiley
Copyright
© 2017 by the Wound Healing Society
ISSN
1067-1927
eISSN
1524-475X
D.O.I.
10.1111/wrr.12609
Publisher site
See Article on Publisher Site

Abstract

NPWT with instillation and dwell time (NPWTi‐d), which combines NPWT with wound irrigation, has been clinically applied as a more effective treatment than conventional NPWT. Commercially available recombinant human basic fibroblast growth factor (rh‐bFGF) has been demonstrated to be beneficial for use over the wound beds. The objective of this study was to evaluate the effectiveness of combined treatment with NPWTi‐d and rh‐bFGF. Six pigs received 12 full‐thickness excisional skin wounds and were treated with six different treatment groups for each pair. The treatment regimens were composed NPWTi‐d, NPWT, or advanced wound care with or without rh‐bFGF. On day 6, the minimum granulation tissue thickness and blood vessel number of the group of combined treatment with NPWTi‐d and rh‐bFGF spray were significantly greater than that of the control group. Combined treatment with NPWTi‐d and rh‐bFGF spray reads to good granulation tissue formation and vascularization for accelerating wound healing.

Journal

Wound Repair and RegenerationWiley

Published: Jan 1, 2017

References

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