Evaluation of the advantages of platelet concentrates stored at 4°C versus 22°C

Evaluation of the advantages of platelet concentrates stored at 4°C versus 22°C ABBREVIATIONSACAarachidonic acidCIcoagulation indexCOLLcollagenctCO2carbon dioxide concentrationEPIepinephrineGapanion gapGLUglucoseHCO3–bicarbonateHSRhypotonic shock reaction rateKkinetics clot formation timeMAmaximum amplitudeMPAR(s)maximum platelet aggregation rate(s)MPVmean platelet volumepCO2partial pressure of carbon dioxidePDWplatelet distribution widthpO2partial pressure of oxygenRreaction timeSEMscanning electronic microscopeTEGthromboelastographyPlatelet (PLT) transfusion plays an irreplaceable role in the prevention and treatment of thrombocytopenia, therapy for surgical trauma, and rescue treatment of patients with massive blood loss. However, PLTs in China are usually stored at 20 to 24°C, and the storage time is limited to 5 days. Given the requirement of a short‐time storage, it is difficult to collect and prepare PLTs. On the one hand, the collection and preparation of PLTs in a large amount is likely to cause PLTs to expire and be wasted; on the other hand, the collection of PLTs in too low of an amount would result in insufficiency of PLT supply, thereby making it difficult to meet the needs of clinical rescue treatment. A method that enables the long‐term storage of PLTs with low loss of PLT function would resolve PLT supply insufficiency.In 1969, Murphy and Gardner compared the PLT storage effect on PLT transfusion in humans; they found that PLTs stored at 22°C could survive in the body for 7 to 9 days, while http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transfusion Wiley

Evaluation of the advantages of platelet concentrates stored at 4°C versus 22°C

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 AABB
ISSN
0041-1132
eISSN
1537-2995
D.O.I.
10.1111/trf.14462
Publisher site
See Article on Publisher Site

Abstract

ABBREVIATIONSACAarachidonic acidCIcoagulation indexCOLLcollagenctCO2carbon dioxide concentrationEPIepinephrineGapanion gapGLUglucoseHCO3–bicarbonateHSRhypotonic shock reaction rateKkinetics clot formation timeMAmaximum amplitudeMPAR(s)maximum platelet aggregation rate(s)MPVmean platelet volumepCO2partial pressure of carbon dioxidePDWplatelet distribution widthpO2partial pressure of oxygenRreaction timeSEMscanning electronic microscopeTEGthromboelastographyPlatelet (PLT) transfusion plays an irreplaceable role in the prevention and treatment of thrombocytopenia, therapy for surgical trauma, and rescue treatment of patients with massive blood loss. However, PLTs in China are usually stored at 20 to 24°C, and the storage time is limited to 5 days. Given the requirement of a short‐time storage, it is difficult to collect and prepare PLTs. On the one hand, the collection and preparation of PLTs in a large amount is likely to cause PLTs to expire and be wasted; on the other hand, the collection of PLTs in too low of an amount would result in insufficiency of PLT supply, thereby making it difficult to meet the needs of clinical rescue treatment. A method that enables the long‐term storage of PLTs with low loss of PLT function would resolve PLT supply insufficiency.In 1969, Murphy and Gardner compared the PLT storage effect on PLT transfusion in humans; they found that PLTs stored at 22°C could survive in the body for 7 to 9 days, while

Journal

TransfusionWiley

Published: Jan 1, 2018

References

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