INTRODUCTIONEpilepsy is one of the most common chronic disorders of the central nervous system, which has been known since ancient times and is characterized by recurrent unprovoked seizures. Due to its chronic nature, it usually requires a long‐term or even lifelong drug therapy except for some special types of seizures. Higher incidences of reproductive hormone dysregulation and sexual dysfunction are reported in epileptic patients compared to healthy individuals, but the causes are still controversial. Incidence of hyposexuality or sexual dysfunction in male epileptic patients varies among the communities with a reported wide range of 20%‐67%. Pathologic electrical activity during an epileptic seizure, psychosocial factors and antiepileptic drugs (AEDs) used are considered to contribute to the development of hyposexuality and alterations of reproductive hormone levels.It is a usual opinion that the antiepileptic drugs may affect hormonal functions, thereby leading to hyposexuality. AEDs cause inhibition of free testosterone (fT) synthesis by a direct effect on testes or decrease fT levels by increasing the levels of sex hormone‐binding globulin (SHBG) and serum estradiol (E2) as a consequence of enzyme induction. There are also studies which showed that the AEDs may lead to sexual dysfunction by affecting the sperm concentration and morphology in
Acta Neurologica Scandinavica – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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