Evaluation of sex hormones and sperm parameters in male epileptic patients

Evaluation of sex hormones and sperm parameters in male epileptic patients INTRODUCTIONEpilepsy is one of the most common chronic disorders of the central nervous system, which has been known since ancient times and is characterized by recurrent unprovoked seizures. Due to its chronic nature, it usually requires a long‐term or even lifelong drug therapy except for some special types of seizures. Higher incidences of reproductive hormone dysregulation and sexual dysfunction are reported in epileptic patients compared to healthy individuals, but the causes are still controversial. Incidence of hyposexuality or sexual dysfunction in male epileptic patients varies among the communities with a reported wide range of 20%‐67%. Pathologic electrical activity during an epileptic seizure, psychosocial factors and antiepileptic drugs (AEDs) used are considered to contribute to the development of hyposexuality and alterations of reproductive hormone levels.It is a usual opinion that the antiepileptic drugs may affect hormonal functions, thereby leading to hyposexuality. AEDs cause inhibition of free testosterone (fT) synthesis by a direct effect on testes or decrease fT levels by increasing the levels of sex hormone‐binding globulin (SHBG) and serum estradiol (E2) as a consequence of enzyme induction. There are also studies which showed that the AEDs may lead to sexual dysfunction by affecting the sperm concentration and morphology in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Neurologica Scandinavica Wiley

Evaluation of sex hormones and sperm parameters in male epileptic patients

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
ISSN
0001-6314
eISSN
1600-0404
D.O.I.
10.1111/ane.12892
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONEpilepsy is one of the most common chronic disorders of the central nervous system, which has been known since ancient times and is characterized by recurrent unprovoked seizures. Due to its chronic nature, it usually requires a long‐term or even lifelong drug therapy except for some special types of seizures. Higher incidences of reproductive hormone dysregulation and sexual dysfunction are reported in epileptic patients compared to healthy individuals, but the causes are still controversial. Incidence of hyposexuality or sexual dysfunction in male epileptic patients varies among the communities with a reported wide range of 20%‐67%. Pathologic electrical activity during an epileptic seizure, psychosocial factors and antiepileptic drugs (AEDs) used are considered to contribute to the development of hyposexuality and alterations of reproductive hormone levels.It is a usual opinion that the antiepileptic drugs may affect hormonal functions, thereby leading to hyposexuality. AEDs cause inhibition of free testosterone (fT) synthesis by a direct effect on testes or decrease fT levels by increasing the levels of sex hormone‐binding globulin (SHBG) and serum estradiol (E2) as a consequence of enzyme induction. There are also studies which showed that the AEDs may lead to sexual dysfunction by affecting the sperm concentration and morphology in

Journal

Acta Neurologica ScandinavicaWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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