Evaluation of routine anti‐HBc screening of volunteer blood donors: a questionable surrogate test for non‐A, non‐B hepatitis

Evaluation of routine anti‐HBc screening of volunteer blood donors: a questionable surrogate... ABSTRACT: Routine antibody to hepatitis B core antigen (anti‐HBc) screening, recommended as a surrogate test to identify potential carriers of non‐ A, non‐B hepatitis, was evaluated on 22,346 blood donors using currently available enzyme immunoassay (EIA) reagents. Of the 2 percent found reactive, the majority had cutoff‐to‐sample absorbance ratios < 2.0 and < one‐half had anti‐HBc when tested by a radioimmunoassay (RIA) method. Only one of 2877 units donated previously by the reactive donors was implicated in a transfusion associated hepatitis case. These results raise questions about the use of currently available anti‐HBc reagents as a surrogate test for non‐A, non‐B hepatitis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transfusion Wiley

Evaluation of routine anti‐HBc screening of volunteer blood donors: a questionable surrogate test for non‐A, non‐B hepatitis

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Abstract

ABSTRACT: Routine antibody to hepatitis B core antigen (anti‐HBc) screening, recommended as a surrogate test to identify potential carriers of non‐ A, non‐B hepatitis, was evaluated on 22,346 blood donors using currently available enzyme immunoassay (EIA) reagents. Of the 2 percent found reactive, the majority had cutoff‐to‐sample absorbance ratios < 2.0 and < one‐half had anti‐HBc when tested by a radioimmunoassay (RIA) method. Only one of 2877 units donated previously by the reactive donors was implicated in a transfusion associated hepatitis case. These results raise questions about the use of currently available anti‐HBc reagents as a surrogate test for non‐A, non‐B hepatitis.

Journal

TransfusionWiley

Published: Jan 2, 1987

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