INTRODUCTIONAspirin and clopidogrel significantly reduce the risk of myocardial infarction (MI), stroke, vascular events or cardiovascular death compared with placebo. According to the current American College of Cardiology (ACC)/American Heart Association (AHA) guidelines, dual antiplatelet therapy (DAPT) is recommended after percutaneous coronary and peripheral vascular interventions, MI and ischemic stroke.However, these benefits are offset to some degree by an increased risk of bleeding, especially gastrointestinal (GI) bleeding. Several large randomized cardiovascular trials have confirmed the association of DAPT with an increased risk of GI bleeding compared with aspirin therapy alone. In patients undergoing percutaneous coronary intervention, GI bleeding is a common cause of non‐access site bleeding and has been associated with increased inpatient morbidity and mortality.However, while a plethora of large‐scale studies show the incidence, predictors and prognosis of DAPT‐related GI bleeding, there is a relative paucity of evidence on the etiology of such bleeding. This is mostly because these large randomized studies were performed to assess the effect of DAPT on cardiovascular outcomes, and GI bleeding was only one out of a large number of events that were recorded. These studies did not report on the etiology of GI bleeding, just on their incidences and severity. The available
Journal of Digestive Diseases – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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