Establishment of multiple lymphoblastoid lines from single lymph nodes and study of their immunoglobulin synthesis

Establishment of multiple lymphoblastoid lines from single lymph nodes and study of their... Biopsies of one normal lymph node and two lymphomas were explanted into a number of independent cultures. Lymphoblastoid lines were established from a high proportion of the cultures from each biopsy. The immunoglobulins synthesized by each line were characterized and used as cell markers in an attempt to obtain information on the cellular origin of the lines. The majority of the lines produced, at the beginning of their culture history, several types of heavy and light chains, but this pattern evolved in the course of cultivation towards the production of only one species of immunoglobulin. Lines from the same lymph node differed from each other by the types of immunoglobulins produced, both initially and at a later stage. The results suggest that lymphoblastoid lines are derived from a non‐clonal population of precursor cells, and argue against the neoplastic nature of these cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Cancer Wiley

Establishment of multiple lymphoblastoid lines from single lymph nodes and study of their immunoglobulin synthesis

Loading next page...
 
/lp/wiley/establishment-of-multiple-lymphoblastoid-lines-from-single-lymph-nodes-HUDzIDWJTC
Publisher
Wiley
Copyright
Copyright © 1973 Wiley‐Liss, Inc., A Wiley Company
ISSN
0020-7136
eISSN
1097-0215
DOI
10.1002/ijc.2910110107
Publisher site
See Article on Publisher Site

Abstract

Biopsies of one normal lymph node and two lymphomas were explanted into a number of independent cultures. Lymphoblastoid lines were established from a high proportion of the cultures from each biopsy. The immunoglobulins synthesized by each line were characterized and used as cell markers in an attempt to obtain information on the cellular origin of the lines. The majority of the lines produced, at the beginning of their culture history, several types of heavy and light chains, but this pattern evolved in the course of cultivation towards the production of only one species of immunoglobulin. Lines from the same lymph node differed from each other by the types of immunoglobulins produced, both initially and at a later stage. The results suggest that lymphoblastoid lines are derived from a non‐clonal population of precursor cells, and argue against the neoplastic nature of these cells.

Journal

International Journal of CancerWiley

Published: Jan 15, 1973

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off