Epigenetic down‐regulation of SOX2 is an independent poor prognostic factor for hypopharyngeal cancers

Epigenetic down‐regulation of SOX2 is an independent poor prognostic factor for hypopharyngeal... IntroductionAlthough most head and neck cancers are histologically squamous cell carcinomas, they are biologically heterogeneous despite their similar microscopic appearance. Hypopharyngeal squamous cell carcinoma (HPSCC) is the most aggressive neoplasm at these anatomical sites, with a 5‐year overall survival rate of between 20% and 40%. Although a multidisciplinary approach is widely used in the clinical management of HPSCCs, high rates of regional recurrence and distant metastasis are factors that significantly affect patient survival. A subset (~60%) of oropharyngeal squamous cell carcinomas (OPSCCs) are caused by infection with human papillomavirus (HPV) and are less aggressive than non‐HPV‐related cases. In contrast, the association with HPV infection is far less common in HPSCCs, and its clinical significance at this site is unclear. Greater understanding of the molecular features of HPSCCs and OPSCCs may be useful for improving treatment efficacy and developing novel therapeutic schemes. The combined use of biomarkers and a traditional TNM classification may also be effective for the stratification of patients in terms of the risk of metastasis and prognoses.Recent studies have demonstrated that a small subset of tumour cells known as cancer stem cells, which show similar characteristics to normal stem cells (e.g. self‐renewal capacity and pluripotency), may be http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Histopathology Wiley

Epigenetic down‐regulation of SOX2 is an independent poor prognostic factor for hypopharyngeal cancers

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Publisher
Wiley
Copyright
Copyright © 2018 John Wiley & Sons Ltd
ISSN
0309-0167
eISSN
1365-2559
D.O.I.
10.1111/his.13436
Publisher site
See Article on Publisher Site

Abstract

IntroductionAlthough most head and neck cancers are histologically squamous cell carcinomas, they are biologically heterogeneous despite their similar microscopic appearance. Hypopharyngeal squamous cell carcinoma (HPSCC) is the most aggressive neoplasm at these anatomical sites, with a 5‐year overall survival rate of between 20% and 40%. Although a multidisciplinary approach is widely used in the clinical management of HPSCCs, high rates of regional recurrence and distant metastasis are factors that significantly affect patient survival. A subset (~60%) of oropharyngeal squamous cell carcinomas (OPSCCs) are caused by infection with human papillomavirus (HPV) and are less aggressive than non‐HPV‐related cases. In contrast, the association with HPV infection is far less common in HPSCCs, and its clinical significance at this site is unclear. Greater understanding of the molecular features of HPSCCs and OPSCCs may be useful for improving treatment efficacy and developing novel therapeutic schemes. The combined use of biomarkers and a traditional TNM classification may also be effective for the stratification of patients in terms of the risk of metastasis and prognoses.Recent studies have demonstrated that a small subset of tumour cells known as cancer stem cells, which show similar characteristics to normal stem cells (e.g. self‐renewal capacity and pluripotency), may be

Journal

HistopathologyWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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