Epigenetic changes and their implications in autoimmune hepatitis

Epigenetic changes and their implications in autoimmune hepatitis INTRODUCTIONAutoimmune hepatitis is a complex immune‐mediated liver disease of unknown cause . A genetic predisposition has been described based mainly on the association of autoimmune hepatitis with certain human leucocyte antigens (HLAs) . These genetic associations have varied in different ethnicities and age groups. HLA DRB1*0301 and DRB1*0401 have been the principal genetic associations in White northern European and North American adults . HLA DRB1*0404 and DRB1*0405 have been associated with the disease in Japan , mainland China and Mexico ; HLA DRB1*0405 and DQB1*0401 have distinguished patients in South Korea ; and HLA DRB1*1301, DRB1*0405, DQB1*02 and DQB1*0603 have been implicated in South American patients by meta‐analysis . Furthermore, children in South America have had a different HLA phenotype (HLA DRB1*1301) than adults from the same region (HLA DRB1*0405) , and North American , South American and European children with autoimmune hepatitis and antibodies to liver kidney microsome type 1 (anti‐LKM1) have been distinguished by HLA DQB1*0201, DRB1*07 and DRB1*03.The association of autoimmune hepatitis with diverse class II antigens of the major histocompatibility complex (MHC) suggests that genetic predisposition for the disease is based mainly on the selection and presentation of triggering peptides that vary in different countries, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Investigation Wiley

Epigenetic changes and their implications in autoimmune hepatitis

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd
ISSN
0014-2972
eISSN
1365-2362
D.O.I.
10.1111/eci.12899
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONAutoimmune hepatitis is a complex immune‐mediated liver disease of unknown cause . A genetic predisposition has been described based mainly on the association of autoimmune hepatitis with certain human leucocyte antigens (HLAs) . These genetic associations have varied in different ethnicities and age groups. HLA DRB1*0301 and DRB1*0401 have been the principal genetic associations in White northern European and North American adults . HLA DRB1*0404 and DRB1*0405 have been associated with the disease in Japan , mainland China and Mexico ; HLA DRB1*0405 and DQB1*0401 have distinguished patients in South Korea ; and HLA DRB1*1301, DRB1*0405, DQB1*02 and DQB1*0603 have been implicated in South American patients by meta‐analysis . Furthermore, children in South America have had a different HLA phenotype (HLA DRB1*1301) than adults from the same region (HLA DRB1*0405) , and North American , South American and European children with autoimmune hepatitis and antibodies to liver kidney microsome type 1 (anti‐LKM1) have been distinguished by HLA DQB1*0201, DRB1*07 and DRB1*03.The association of autoimmune hepatitis with diverse class II antigens of the major histocompatibility complex (MHC) suggests that genetic predisposition for the disease is based mainly on the selection and presentation of triggering peptides that vary in different countries,

Journal

European Journal of Clinical InvestigationWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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