Epidermal Growth Factor in Synaptosomal Fractions of Mouse Cerebral Cortex

Epidermal Growth Factor in Synaptosomal Fractions of Mouse Cerebral Cortex Abstract: Using a specific and sensitive epidermal growth factor radioimmunoassay (EGF‐RIA) we measured EGF concentrations in whole brain, cerebral cortex, and cerebral cortical synaptosomal (pinched‐off presynaptic nerve terminals) fractions of 26‐day‐old mouse brain. The relative EGF concentration in synaptosomal fractions was significantly greater than the growth factor concentrations in whole brain or cerebral cortex. Intracerebral injection, in an amount of EGF, several‐fold greater than whole brain EGF content, did not appreciably increase synaptosomal EGF concentration, suggesting that no artifact was involved. The high synaptosomal EGF content suggests a neurotransmitter or a neuromodulator role for EGF in the CNS. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

Epidermal Growth Factor in Synaptosomal Fractions of Mouse Cerebral Cortex

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Publisher
Wiley
Copyright
Copyright © 1986 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
D.O.I.
10.1111/j.1471-4159.1986.tb00621.x
Publisher site
See Article on Publisher Site

Abstract

Abstract: Using a specific and sensitive epidermal growth factor radioimmunoassay (EGF‐RIA) we measured EGF concentrations in whole brain, cerebral cortex, and cerebral cortical synaptosomal (pinched‐off presynaptic nerve terminals) fractions of 26‐day‐old mouse brain. The relative EGF concentration in synaptosomal fractions was significantly greater than the growth factor concentrations in whole brain or cerebral cortex. Intracerebral injection, in an amount of EGF, several‐fold greater than whole brain EGF content, did not appreciably increase synaptosomal EGF concentration, suggesting that no artifact was involved. The high synaptosomal EGF content suggests a neurotransmitter or a neuromodulator role for EGF in the CNS.

Journal

Journal of NeurochemistryWiley

Published: Apr 1, 1986

References

  • Rapid induction of morphological changes in human carcinoma cells A‐431 by epidermal growth factor
    Chinkers, Chinkers; McKanna, McKanna; Cohen, Cohen
  • Epidermal growth factor induces tyrosine hydroxylase in a clonal pheochromocytoma cell line, PC‐G2
    Goodman, Goodman; Slater, Slater; Herschman, Herschman
  • Epidermal growth factor inhibits cytoskeleton related changes in the surface of parietal cells
    Gonzalez, Gonzalez; Garrido, Garrido; Vial, Vial
  • Growth factors in mammalian cell culture
    Gospodarowicz, Gospodarowicz; Moran, Moran
  • Epidermal growth factor binding and mitogenic activity on purified populations of cells from the central nervous system
    Simpson, Simpson; Morrison, Morrison; Vellis, Vellis; Herschman, Herschman
  • A nonmitogenic analogue of epidermal growth factor induces early responses mediated by epidermal growth factor
    Yarden, Yarden; Schrieber, Schrieber; Schlessinger, Schlessinger

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