Skin and Eye Diseases
Epidemiology of atopic dermatitis in adults: Results from an
E. L. Simpson
D. J. Margolis
M. de Bruin-Weller
Department of Dermatology, CHU Nantes,
Kantar Health, Paris, France
Regeneron, Tarrytown, NY, USA
Department of Medicine, Section of
Dermatology, University of Verona, Verona,
Hospital de la Santa Creu i Sant Pau,
onoma de Barcelona,
Department of Dermatology, Oregon
Health & Science University, Portland, OR,
Department of Dermatology, University of
Pennsylvania Perelman School of Medicine,
Philadelphia, PA, USA
Department of Dermatology & Allergology,
University Medical Center Utrecht, Utrecht,
Sanofi, Chilly-Mazarin, France
Sebastien Barbarot, MD, PhD, Service de
Dermatologie, Centre Hospitalier
Universitaire de Nantes, Nantes, France.
This study was funded by Regeneron
Pharmaceuticals, Inc. and Sanofi.
Background: There are gaps in our knowledge of the prevalence of adult atopic
Objective: To estimate the prevalence of AD in adults and by disease severity.
Methods: This international, cross-sectional, web-based survey was performed in
the United States, Canada, France, Germany, Italy, Spain, United Kingdom, and
Japan. Adult members of online respondent panels were sent a questionnaire for
AD identification and severity assessment; demographic quotas ensured population
representativeness for each country. A diagnosis of AD required subjects to be posi-
tive on the modified UK Working Party/ISAAC criteria and self-report of ever hav-
ing an AD diagnosis by a physician. The proportion of subjects with AD who
reported being treated for their condition was determined and also used to estimate
prevalence. Severity scales were Patient-Oriented SCORAD, Patient-Orientated
Eczema Measure, and Patient Global Assessment.
Results: Among participants by region, the point prevalence of adult AD in the over-
all/treated populations was 4.9%/3.9% in the US, 3.5%/2.6% in Canada, 4.4%/3.5% in
the EU, and 2.1%/1.5% in Japan. The prevalence was generally lower for males vs
females, and decreased with age. Regional variability was observed within countries.
Severity varied by scale and region; however, regardless of the scale or region, propor-
tion of subjects reporting severe disease was lower than mild or moderate disease.
Conclusions: Prevalence of adult AD ranged from 2.1% to 4.9% across countries.
Severe AD represented a small proportion of the overall AD population regardless
of measure or region.
atopic dermatitis, epidemiology, prevalence, severity
Atopic dermatitis (AD) is a chronic, complex, often relapsing inflam-
matory skin disease. The clinical presentation of AD includes pruri-
tus, xerosis, and eczematous lesions, and its pathology is
characterized by interactions between skin barrier defects and
immune dysregulation, with recent evidence suggesting that it is a
There is a consistent association of AD with
other atopic and allergic conditions including asthma and atopic
rhinitis, often in a progression known as the atopic march.
den of illness associated with AD has been well characterized in the
pediatric population, including recognition of the impact of AD on
Accepted: 2 January 2018
© 2018 EAACI and John Wiley and Sons A/S.
Published by John Wiley and Sons Ltd.
wileyonlinelibrary.com/journal/all Allergy. 2018;73:1284–1293.