Enlargement of human cerebral ischemic lesion volumes measured by diffusion‐weighted magnetic resonance imaging

Enlargement of human cerebral ischemic lesion volumes measured by diffusion‐weighted magnetic... We aimed to determine the frequency and time course of the enlargement of ischemic cerebral lesions following human stroke and to study the effect of the state of perfusion on lesion enlargement. Acute lesion volumes were measured on diffusion‐weighted magnetic resonance images and compared with lesion volumes measured on T2‐weighted images at 7 days or later. Forty‐four measurements were performed between 2 and 53 hours after stroke onset in 28 patients. Thirteen patients also had magnetic resonance perfusion imaging performed. In 12 (43%) of 28 patients the initial lesion volume increased by 20% or more. The number of studies showing enlargement of the ischemic lesion volume ranged from 12 (43%) of 28 at or after 2 hours to 10 (38%) of 26 at or after 6 hours, 5 (33%) of 15 at or after 24 hours, and 2 (33%) of 6 at or after 48 hours. In 7 of the 10 patients in whom the hypoperfusion volume acutely exceeded the volume of the abnormality on diffusion‐weighted images, lesion volume increased by 20% or more. This study provided evidence that substantial enlargement of human cerebral ischemic lesion volumes can occur beyond the first 6, 12 or 24 hours after onset. A mismatch acutely between the region of hypoperfusion (larger) and the region of diffusion abnormality (smaller) may be predictive of ischemic lesion enlargement. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Neurology Wiley

Enlargement of human cerebral ischemic lesion volumes measured by diffusion‐weighted magnetic resonance imaging

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Publisher
Wiley
Copyright
Copyright © 1997 American Neurological Association
ISSN
0364-5134
eISSN
1531-8249
D.O.I.
10.1002/ana.410410506
Publisher site
See Article on Publisher Site

Abstract

We aimed to determine the frequency and time course of the enlargement of ischemic cerebral lesions following human stroke and to study the effect of the state of perfusion on lesion enlargement. Acute lesion volumes were measured on diffusion‐weighted magnetic resonance images and compared with lesion volumes measured on T2‐weighted images at 7 days or later. Forty‐four measurements were performed between 2 and 53 hours after stroke onset in 28 patients. Thirteen patients also had magnetic resonance perfusion imaging performed. In 12 (43%) of 28 patients the initial lesion volume increased by 20% or more. The number of studies showing enlargement of the ischemic lesion volume ranged from 12 (43%) of 28 at or after 2 hours to 10 (38%) of 26 at or after 6 hours, 5 (33%) of 15 at or after 24 hours, and 2 (33%) of 6 at or after 48 hours. In 7 of the 10 patients in whom the hypoperfusion volume acutely exceeded the volume of the abnormality on diffusion‐weighted images, lesion volume increased by 20% or more. This study provided evidence that substantial enlargement of human cerebral ischemic lesion volumes can occur beyond the first 6, 12 or 24 hours after onset. A mismatch acutely between the region of hypoperfusion (larger) and the region of diffusion abnormality (smaller) may be predictive of ischemic lesion enlargement.

Journal

Annals of NeurologyWiley

Published: May 1, 1997

References

  • Temporal profile of neuronal damage in a model of transient ischemia
    Pulsinelli, Pulsinelli; Brierley, Brierley; Plum, Plum
  • Adhesion receptors of the immune system
    Springer, Springer
  • Viability thresholds and the penumbra of focal ischemia
    Hossmann, Hossmann
  • Neurobehavioral consequences of inducing spreading depression following photothrombotic middle cerebral artery occlusion
    Alexis, Alexis; Back, Back; Zhao, Zhao

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