Two and a half years ago, in 2015, Biotechnology Journal released a special issue on Mammalian Production Systems with an Editorial entitled “On the cusp of rational cell engineering.” This title was chosen to express the expectancy, arising from recent developments such as the release of the CHO and Chinese hamster genomes, to understand in unprecedented detail the molecular and biochemical mechanisms at work in mammalian cell lines used for the production of biopharmaceutics. Since then, we have seen the publication of genome sequences for several more cell lines, of a plethora of transcriptome and proteome datasets and the first exploration of the impact of epigenetics on cellular behavior in bioprocessing, along with the advent of highly efficient and targeted genome editing tools such as CRISPR/Cas9, which have considerably enhanced the scope and speed of cell line engineering.Due to the importance of biopharmaceutics for research, medicine and industry, the European Union realized the urgency of having appropriately trained individuals in their workforce, able to handle the associated multi‐disciplinary challenges. Therefore, an International Training Network on “enhancing CHO by systems biology,” in short eCHO, was established within the EU Marie‐Curie Actions Program, to train 15 PhD students in the diverse
Biotechnology Journal – Wiley
Published: Jan 1, 2018
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