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Enhancement of mechanical performance of striated muscle by stretch during contraction

Enhancement of mechanical performance of striated muscle by stretch during contraction M. I. M. NOBLE Academic Unit of Cardiovascular Medicine, Charing Cross and Westminster Medical School, 17 Horseferry Road, London SW1P 2AR (MANUSCRIPT RECEIVED 30 SEPTEMBER 1991, ACCEPTED 6 JANUARY 1992) CONTENTS PAGE Introduction The experimental data Force enhancement during and after stretch Component 1: velocity-dependent force enhancement during stretch Component 2: a force component recruited by a critical sarcomere extension (not increased by further extension), which decays with time Component 3: residual force enhancement after stretch of contracting muscle Structural explanations of force enhancement by active stretch: connectin and nebulin X-ray diffraction studies Energetic considerations: heat production and ATP consumption Simulation of force enhancement by active stretch by muscle models Conclusion References INTRODUCTION Most physiologists and medical students know that when a striated muscle is stimulated, if that muscle has been stretched at rest beyond the optimum length for overlap of actin and myosin filaments, there is a reduction in force production (Ramsey & Street, 1940; Edman, 1966; Gordon, Huxley & Julian, 1966). Fewer know that stretch of striated muscle whilst contracting beyond the optimum length for overlap of actin and myosin filaments increases force production which then remains at a higher level (Fenn, 1924; Abbot, Aubert & http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Physiology Wiley

Enhancement of mechanical performance of striated muscle by stretch during contraction

Experimental Physiology , Volume 77 (4) – Jul 1, 1992

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References (45)

Publisher
Wiley
Copyright
© 2014 The Physiological Society
ISSN
0958-0670
eISSN
1469-445X
DOI
10.1113/expphysiol.1992.sp003618
Publisher site
See Article on Publisher Site

Abstract

M. I. M. NOBLE Academic Unit of Cardiovascular Medicine, Charing Cross and Westminster Medical School, 17 Horseferry Road, London SW1P 2AR (MANUSCRIPT RECEIVED 30 SEPTEMBER 1991, ACCEPTED 6 JANUARY 1992) CONTENTS PAGE Introduction The experimental data Force enhancement during and after stretch Component 1: velocity-dependent force enhancement during stretch Component 2: a force component recruited by a critical sarcomere extension (not increased by further extension), which decays with time Component 3: residual force enhancement after stretch of contracting muscle Structural explanations of force enhancement by active stretch: connectin and nebulin X-ray diffraction studies Energetic considerations: heat production and ATP consumption Simulation of force enhancement by active stretch by muscle models Conclusion References INTRODUCTION Most physiologists and medical students know that when a striated muscle is stimulated, if that muscle has been stretched at rest beyond the optimum length for overlap of actin and myosin filaments, there is a reduction in force production (Ramsey & Street, 1940; Edman, 1966; Gordon, Huxley & Julian, 1966). Fewer know that stretch of striated muscle whilst contracting beyond the optimum length for overlap of actin and myosin filaments increases force production which then remains at a higher level (Fenn, 1924; Abbot, Aubert &

Journal

Experimental PhysiologyWiley

Published: Jul 1, 1992

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