Enhanced serum levels of matrix Gla protein and bone morphogenetic protein in acute coronary syndrome patients

Enhanced serum levels of matrix Gla protein and bone morphogenetic protein in acute coronary... INTRODUCTIONVascular calcification has been found to be associated with three‐ to fourfold increased risk of cardiovascular (CV) morbidity and mortality. Calcium deposition in the coronary arteries, also referred to as coronary artery calcium (CAC), and its progression has been associated with future coronary heart disease (CHD) events, including myocardial infarction (MI). Promotion of vascular calcification has been attributed to the de‐differentiation of vascular smooth muscle cells (VSMCs) into osteoblast‐like phenotype. A number of studies have demonstrated the presence of bone‐associated proteins, such as osteopontin, osteocalcin, bone morphogenic protein (BMP)‐2, osteonectin, and matrix Gla protein (MGP) in human calcified, atherosclerotic plaques. In this study, we aimed to evaluate whether serum levels of BMP‐4 and MGP differed in patients who were found to have normal epicardial coronary arteries or a culprit lesion in the coronary angiography leading to acute coronary syndrome (ACS).MATERIALS AND METHODSStudy populationPatients admitted to emergency department with the diagnosis of ACS who underwent primary percutaneous coronary intervention (PCI) between October 2015 and April 2016 were consecutively recruited as the patient group. Age and gender‐matched subjects who underwent coronary angiography following non‐invasive ischemia assessment made the control group. Exclusion criteria were determined as a prior diagnosis of chronic kidney http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Laboratory Analysis Wiley

Enhanced serum levels of matrix Gla protein and bone morphogenetic protein in acute coronary syndrome patients

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Wiley Periodicals, Inc.
ISSN
0887-8013
eISSN
1098-2825
D.O.I.
10.1002/jcla.22278
Publisher site
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Abstract

INTRODUCTIONVascular calcification has been found to be associated with three‐ to fourfold increased risk of cardiovascular (CV) morbidity and mortality. Calcium deposition in the coronary arteries, also referred to as coronary artery calcium (CAC), and its progression has been associated with future coronary heart disease (CHD) events, including myocardial infarction (MI). Promotion of vascular calcification has been attributed to the de‐differentiation of vascular smooth muscle cells (VSMCs) into osteoblast‐like phenotype. A number of studies have demonstrated the presence of bone‐associated proteins, such as osteopontin, osteocalcin, bone morphogenic protein (BMP)‐2, osteonectin, and matrix Gla protein (MGP) in human calcified, atherosclerotic plaques. In this study, we aimed to evaluate whether serum levels of BMP‐4 and MGP differed in patients who were found to have normal epicardial coronary arteries or a culprit lesion in the coronary angiography leading to acute coronary syndrome (ACS).MATERIALS AND METHODSStudy populationPatients admitted to emergency department with the diagnosis of ACS who underwent primary percutaneous coronary intervention (PCI) between October 2015 and April 2016 were consecutively recruited as the patient group. Age and gender‐matched subjects who underwent coronary angiography following non‐invasive ischemia assessment made the control group. Exclusion criteria were determined as a prior diagnosis of chronic kidney

Journal

Journal of Clinical Laboratory AnalysisWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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