INTRODUCTIONAtmospheric‐pressure (AP) cold plasma‐enhanced chemical vapor deposition (PECVD) of thin coatings destined for biomedical applications is a vast, ever‐growing field. One of the main reasons is that AP plasmas, like their low‐pressure (LP) counterparts, enable fine surface engineering but also promise more economical, easier implementation by obviating the need for costly vacuum installations.This work focuses on anti‐fouling poly(ethylene glycol)‐like (PEG‐like) coatings, known to inhibit protein adsorption thanks notably to strong water‐PEG interactions; as a result, they have the potential to prevent adhesion of cells and bacteria, inflammatory reactions and other undesired “wall‐off” reactions from the biological environment (eg, collagenous encapsulating response). These particular interactions with water render conventional PEG—also referred to as poly(ethylene oxide) (PEO)—completely soluble in water, in all proportions and for all degrees of polymerization at room temperature. As a result, PEG cannot be used as a single material for manufacturing medical devices. Various solutions have been envisaged, all with the aim of introducing PEG chains either into (a) PEG‐containing copolymers, or onto the surface of another material by way of (b) physisorption, or (c) covalent grafting. Materials and surfaces produced in this way nevertheless have certain drawbacks, namely low strength for (a); for the case of
Plasma Processes and Polymers – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ; ; ;
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