Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis elegans

Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis... SummaryG-proteins, including GPA-3, play an important role in regulating physiological responses in Caenorhabditis elegans. When confronted with an environmental stimulus such as dauer pheromone, or poor nutrients, C. elegans receives and integrates external signals through its nervous system (i.e. amphid neurons), which interprets and translates them into biological action. Here it is shown that a suppressed neuronal cGMP level caused by GPA-3 activation leads to a significant increase (47.3%) in the mean lifespan of adult C. elegans through forkhead transcription factor family O (FOXO)-mediated signal. A reduced neuronal cGMP level was found to be caused by an increased cGMP-specific phosphodiesterase activity at the transcriptional level. Our results using C. elegans mutants with specific deficits in TGF-ॆ and FOXO RNAi system suggest a mechanism in that cGMP, TGF-ॆ, and FOXO signaling interact to differentially produce the insulin-like molecules, ins-7 and daf-28, causing suppression of the insulin/IGF-1 pathway and promoting lifespan extension. Our findings provide not only a new mechanism of cGMP-mediated induction of longevity in adult C. elegans but also a possible therapeutic strategy for neuronal disease, which has been likened to brain diabetes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Aging Cell Wiley

Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis elegans

Hahm, Jeong-Hoon; Kim, Sunhee; Paik, Young-Ki
Aging Cell , Volume 8 (4) – Aug 1, 2009
Download PDF
11 pages

Loading next page...
 
/lp/wiley/endogenous-cgmp-regulates-adult-longevity-via-the-insulin-signaling-tKFQDlmG24

References (58)

Publisher
Wiley
Copyright
Journal compilation © 2009 Blackwell Publishing Ltd/The Anatomical Society of Great Britain and Ireland
ISSN
1474-9718
DOI
10.1111/j.1474-9726.2009.00495.x
pmid
19489741
Publisher site
See Article on Publisher Site

Abstract

SummaryG-proteins, including GPA-3, play an important role in regulating physiological responses in Caenorhabditis elegans. When confronted with an environmental stimulus such as dauer pheromone, or poor nutrients, C. elegans receives and integrates external signals through its nervous system (i.e. amphid neurons), which interprets and translates them into biological action. Here it is shown that a suppressed neuronal cGMP level caused by GPA-3 activation leads to a significant increase (47.3%) in the mean lifespan of adult C. elegans through forkhead transcription factor family O (FOXO)-mediated signal. A reduced neuronal cGMP level was found to be caused by an increased cGMP-specific phosphodiesterase activity at the transcriptional level. Our results using C. elegans mutants with specific deficits in TGF-ॆ and FOXO RNAi system suggest a mechanism in that cGMP, TGF-ॆ, and FOXO signaling interact to differentially produce the insulin-like molecules, ins-7 and daf-28, causing suppression of the insulin/IGF-1 pathway and promoting lifespan extension. Our findings provide not only a new mechanism of cGMP-mediated induction of longevity in adult C. elegans but also a possible therapeutic strategy for neuronal disease, which has been likened to brain diabetes.

Journal

Aging Cell – Wiley

Published: Aug 1, 2009

Keywords: C. elegans ; cGMP; GPA-3; insulin/IGF-1 Pathway; lifespan; phosphodiesterase

There are no references for this article.