Endocrine disorders and laminitis

Endocrine disorders and laminitis Summary Two common endocrine disorders, pituitary pars intermedia dysfunction and equine metabolic syndrome, predispose horses and ponies to laminitis and may even induce the condition. The exact mechanisms involved in endocrinopathic laminitis have not been elucidated but hyperinsulinaemia and insulin resistance are currently being investigated. Obesity and regional adiposity may also contribute to laminitis susceptibility through the release of inflammatory cytokines and adipokines. In the case of pituitary pars intermedia dysfunction, glucocorticoid excess is likely to weaken hoof structures, alter vascular dynamics within the foot and induce or exacerbate insulin resistance. This review will summarise current theories regarding the pathophysiology of endocrinopathic laminitis and provide recommendations for the diagnosis and management of these common equine endocrine disorders. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Equine Veterinary Education Wiley

Endocrine disorders and laminitis

Equine Veterinary Education, Volume 25 (3) – Mar 1, 2013

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Publisher
Wiley
Copyright
© 2013 EVJ Ltd
ISSN
0957-7734
eISSN
2042-3292
D.O.I.
10.1111/j.2042-3292.2011.00327.x
Publisher site
See Article on Publisher Site

Abstract

Summary Two common endocrine disorders, pituitary pars intermedia dysfunction and equine metabolic syndrome, predispose horses and ponies to laminitis and may even induce the condition. The exact mechanisms involved in endocrinopathic laminitis have not been elucidated but hyperinsulinaemia and insulin resistance are currently being investigated. Obesity and regional adiposity may also contribute to laminitis susceptibility through the release of inflammatory cytokines and adipokines. In the case of pituitary pars intermedia dysfunction, glucocorticoid excess is likely to weaken hoof structures, alter vascular dynamics within the foot and induce or exacerbate insulin resistance. This review will summarise current theories regarding the pathophysiology of endocrinopathic laminitis and provide recommendations for the diagnosis and management of these common equine endocrine disorders.

Journal

Equine Veterinary EducationWiley

Published: Mar 1, 2013

References

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