Encapsulation of 5‐Fluorouracil in a Copper(II)‐based Porous Metal‐organic Framework: Drug Delivery and Inhibiting Human Spinal Cord Tumor Cells

Encapsulation of 5‐Fluorouracil in a Copper(II)‐based Porous Metal‐organic Framework: Drug... Solvothermal reaction of a semirigid tricarboxylic acid with Cu(NO3)2·3H2O gives rise to a robust microporous metal‐organic framework with the formula {[Cu2(OH)bcb](DMF)2(H2O)3}n (1) [H3bcb = 3,5‐bis((4′‐carboxylbenzyl)‐oxy)benzoic acid, DMF = N,N‐dimethylformamide]. Its structure was determined by single‐crystal X‐ray diffraction analysis and further characterized by elemental analysis, powder X‐ray diffraction (PXRD), and thermogravimetric (TG) analyses. The efficient encapsulation of an anticancer drug 5‐fluorouracil (5‐Fu) on the desolvated 1 (1a) was studied by both grand canonical Monte Carlo (GCMC) simulation and drug release experiments. In addition, in vitro anticancer activity of compounds 1 and 5‐Fu loaded 1a were also evaluated using MTT assay. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Zaac-Journal of Inorganic and General Chemistry Wiley

Encapsulation of 5‐Fluorouracil in a Copper(II)‐based Porous Metal‐organic Framework: Drug Delivery and Inhibiting Human Spinal Cord Tumor Cells

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
0044-2313
eISSN
1521-3749
D.O.I.
10.1002/zaac.201800003
Publisher site
See Article on Publisher Site

Abstract

Solvothermal reaction of a semirigid tricarboxylic acid with Cu(NO3)2·3H2O gives rise to a robust microporous metal‐organic framework with the formula {[Cu2(OH)bcb](DMF)2(H2O)3}n (1) [H3bcb = 3,5‐bis((4′‐carboxylbenzyl)‐oxy)benzoic acid, DMF = N,N‐dimethylformamide]. Its structure was determined by single‐crystal X‐ray diffraction analysis and further characterized by elemental analysis, powder X‐ray diffraction (PXRD), and thermogravimetric (TG) analyses. The efficient encapsulation of an anticancer drug 5‐fluorouracil (5‐Fu) on the desolvated 1 (1a) was studied by both grand canonical Monte Carlo (GCMC) simulation and drug release experiments. In addition, in vitro anticancer activity of compounds 1 and 5‐Fu loaded 1a were also evaluated using MTT assay.

Journal

Zaac-Journal of Inorganic and General ChemistryWiley

Published: Jan 15, 2018

Keywords: ; ; ;

References

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