AbbreviationsADHDattention‐deficit/hyperactivity disorderCBCLchild behavior checklistIQintelligence quotientNF1neurofibromatosis type 1TRFteacher's Report FormWISC‐III‐NLwechsler intelligence scale for children, third version for the NetherlandsYSRyouth self‐reportINTRODUCTIONNeurofibromatosis type 1 (NF1) is a common genetic disorder, with a birth incidence of at least 1 in 2 700 (Evans et al., ). NF1 is mainly characterized by various progressive neurocutaneous manifestations, including café‐au‐lait spots, skinfold freckling, and neurofibromas. The most frequent complications of NF1 in children are deficits in cognition and behavior (Ferner et al., ). Neuropsychological deficits include a lowered average IQ, as well as problems with academic skills, visuospatial skills, social competence, and attention (Lehtonen, Howie, Trump, & Huson, ). Up to 75% of NF1 children have learning disabilities and the majority of children need additional support, for example, special education and/or remedial teaching (Krab, Aarsen, et al., ). Parental behavioral reports using the Child Behavior Checklist (CBCL) tend to reveal problems predominantly in the internalizing domain, encompassing anxiety, depression, social withdrawal, and somatic complaints (Graf, Landolt, Mori, & Boltshauser, ; Johnson, Saal, Lovell, & Schorry, ).So far, assessments of the behavioral phenotype of children with NF1 have mainly focused on reports by proxies (Barton & North, ; Descheemaeker, Ghesquiere, Symons, Fryns, & Legius, ; Dilts et al.,
American Journal of Medical Genetics – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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