Abstract: Rats were implanted with 0.3‐mm‐diameter dialysis tubing through the hippocampus and subsequently perfused with Ringer's solution at a flow rate of 2 (μ1/min. Samples of the perfusate representing the extracellular fluid were collected over 5‐min periods and subsequently analyzed for contents of the amino acids glutamate, as‐partate, glutamine, taurine, alanine, and serine. Samples were collected before, during, and after a 10‐min period of transient complete cerebral ischemia. The extracellular contents of glutamate and aspartate were increased, respectively, eight‐and threefold during the ischemic period; the taurine concentration also was increased 2.6‐fold. During the same period the extracellular content of glutamine was significantly decreased (to 68% of the control value), whereas the concentrations of alanine and serine did not change significantly during the ischemic period. The concentrations of γ‐aminobutyric acid (GABA) were too low to be measured reliably. It is suggested that the large increase in the content of extracellular glutamate and aspartate in the hippocampus induced by the ischemia may be one of the causal factors in the damage to certain neurons observed after ischemia.
Journal of Neurochemistry – Wiley
Published: Nov 1, 1984
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera