Dear Editor,Propriospinal myoclonus (PSM) is an unusual movement disorder mainly involving abdominal muscles. Based on the etiology of the PSM, it can be classified as idiopathic, secondary and functional. Secondary PSM is usually caused by spinal lesions, and occurrences of drug‐induced PSM are considered extremely rare. We report a case of secondary PSM triggered by intractable nausea and vomiting after administration of memantine and bupropion, suggesting that drug‐induced nausea and vomiting should be considered in the possible etiology of PSM.An 86‐year‐old woman was admitted to Soonchunhyang University Seoul Hospital, Seoul, Korea, because of involuntary movement in the trunk combined with intractable nausea and vomiting. She had been treated for depression for 8 years with antidepressants including fluoxetine and diazepam. Six months earlier, the patient was diagnosed with mixed dementia related to Alzheimer's disease and vascular dementia, and early‐stage Parkinson's disease at our clinic. We administered donepezil, memantine (10 mg/day),and levodopa, and changed the antidepressant drugs to tianeptine (25 mg/day). The doses of the drugs prescribed for depression, dementia and Parkinson's disease were gradually increased every 2 months in the outpatient department. Two weeks before her admission, we increased the dose of memantine (20 mg/day), and changed the antidepressant to
Geriatrics & Gerontology International – Wiley
Published: Jan 1, 2018
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