Eight weeks of omeprazole 20 mg significantly reduces both laryngopharyngeal reflux and comorbid chronic rhinosinusitis signs and symptoms: Randomised, double‐blind, placebo‐controlled trial

Eight weeks of omeprazole 20 mg significantly reduces both laryngopharyngeal reflux and comorbid... KeypointsWe have assessed if GERD‐recommended treatment with PPI (dose and duration) can significantly reduce the signs and symptoms of LPR and comorbid CRS.Treating patients with LPR and comorbid CRS with omeprazole 20 mg OD for 8 weeks significantly reduced both subjective and objective signs and symptoms of LPR and comorbid CRS when compared to placebo.However in most patients (>75%) on active treatment, signs and symptoms were still present at the end of the trial suggesting the need to find the appropriate dose and duration of treatment..INTRODUCTIONChronic rhinosinusitis (CRS) is in the realm of scientific interest, as its aetiology and association with other respiratory and multimorbid disorders have not yet been clarified. It is a public health concern as between 10% and 30% of the adult population suffer from CRS. In patients with CRS, one should rule out or treat allergies, asthma or other underlying conditions as infections, inflammation associated with environmental factors, anatomic alterations or a combination of the mentioned. Latest literature proposes laryngopharyngeal reflux (LPR) as the underlying contributory factor for chronic inflammation in both upper and lower airways. The mechanism leading to airways mucous membrane damage is still not fully understood, but chemical injury induced by low http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Otolaryngology Wiley

Eight weeks of omeprazole 20 mg significantly reduces both laryngopharyngeal reflux and comorbid chronic rhinosinusitis signs and symptoms: Randomised, double‐blind, placebo‐controlled trial

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 John Wiley & Sons Ltd
ISSN
1749-4478
eISSN
1749-4486
D.O.I.
10.1111/coa.13005
Publisher site
See Article on Publisher Site

Abstract

KeypointsWe have assessed if GERD‐recommended treatment with PPI (dose and duration) can significantly reduce the signs and symptoms of LPR and comorbid CRS.Treating patients with LPR and comorbid CRS with omeprazole 20 mg OD for 8 weeks significantly reduced both subjective and objective signs and symptoms of LPR and comorbid CRS when compared to placebo.However in most patients (>75%) on active treatment, signs and symptoms were still present at the end of the trial suggesting the need to find the appropriate dose and duration of treatment..INTRODUCTIONChronic rhinosinusitis (CRS) is in the realm of scientific interest, as its aetiology and association with other respiratory and multimorbid disorders have not yet been clarified. It is a public health concern as between 10% and 30% of the adult population suffer from CRS. In patients with CRS, one should rule out or treat allergies, asthma or other underlying conditions as infections, inflammation associated with environmental factors, anatomic alterations or a combination of the mentioned. Latest literature proposes laryngopharyngeal reflux (LPR) as the underlying contributory factor for chronic inflammation in both upper and lower airways. The mechanism leading to airways mucous membrane damage is still not fully understood, but chemical injury induced by low

Journal

Clinical OtolaryngologyWiley

Published: Jan 1, 2018

References

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