Eicosanoids and inflammation

Eicosanoids and inflammation EICOSANOIDS AND INFLAMMATION K. I. WILLIAMS AND G. A. HIGGS* School o Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7A Y , U. K.; *Department of f Pharmacology, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U . K . Received 20 March 1988 Accepted 20 April 1988 KEY woms-Eicosanoids, prostaglandins,thromboxanes, leukotrienes, inflammation, anti-inflammatory drugs. most important source. The three main phospholipids into which AA is incorporated are phosphatiThe collective term eicosanoid is used to describe dyl choline, phosphatidyl ethanolamine and phosa range of widely differing chemical substances, e.g., phatidyl inositol. Groups of such phospholipid prostaglandins (PGs), thromboxanes (TXs), leuko- molecules in water exist together as a bilayer which trienes (LTs), and hydroxy acids (HETEs), which forms the basis of the cell membrane. Hence, all cell are produced by cells from polyunsaturated fatty membranes contain AA and have the potential acids, particularly arachidonic acid (AA), which capacity to produce eicosanoids when the AA is contain a 20-carbon atom chain. Twenty years ago, released from the phospholipid stores. In order for many of these substances were unknown, but the this to occur, the ester linkage joining AA to the ensuing period has seen a veritable http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Pathology Wiley

Eicosanoids and inflammation

The Journal of Pathology, Volume 156 (2) – Oct 1, 1988

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Publisher
Wiley
Copyright
Copyright © 1988 John Wiley & Sons, Ltd.
ISSN
0022-3417
eISSN
1096-9896
DOI
10.1002/path.1711560204
Publisher site
See Article on Publisher Site

Abstract

EICOSANOIDS AND INFLAMMATION K. I. WILLIAMS AND G. A. HIGGS* School o Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7A Y , U. K.; *Department of f Pharmacology, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U . K . Received 20 March 1988 Accepted 20 April 1988 KEY woms-Eicosanoids, prostaglandins,thromboxanes, leukotrienes, inflammation, anti-inflammatory drugs. most important source. The three main phospholipids into which AA is incorporated are phosphatiThe collective term eicosanoid is used to describe dyl choline, phosphatidyl ethanolamine and phosa range of widely differing chemical substances, e.g., phatidyl inositol. Groups of such phospholipid prostaglandins (PGs), thromboxanes (TXs), leuko- molecules in water exist together as a bilayer which trienes (LTs), and hydroxy acids (HETEs), which forms the basis of the cell membrane. Hence, all cell are produced by cells from polyunsaturated fatty membranes contain AA and have the potential acids, particularly arachidonic acid (AA), which capacity to produce eicosanoids when the AA is contain a 20-carbon atom chain. Twenty years ago, released from the phospholipid stores. In order for many of these substances were unknown, but the this to occur, the ester linkage joining AA to the ensuing period has seen a veritable

Journal

The Journal of PathologyWiley

Published: Oct 1, 1988

References

  • Effect of p ‐bromophenacyl bromide, an inhibitor of phospholipase A 2 , on arachidonic acid release and prostaglandin synthesis by the guinea pig uterus in vitro
    Mitchell, Mitchell; Poyser, Poyser; Wilson, Wilson
  • Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides
    Hamberg, Hamberg; Svensson, Svensson; Sammuelsson, Sammuelsson
  • Leukotriene B: a potential mediator of inflammation
    Smith, Smith; Ford‐Hutchison, Ford‐Hutchison; Bray, Bray
  • Prostaglandin D 2 is the prevailing prostaglandin in the acute inflammatory exudate of urate arthritis in chicken
    Arhut, Arhut; Brune, Brune; Frolich, Frolich
  • The role of prostaglandins in rabbit monoarticular arthritis
    Blackham, Blackham; Farmer, Farmer; Radziwonik, Radziwonik
  • Leukotriene B 4 in synovial fluid
    Davidson, Davidson; Rae, Rae; Smith, Smith
  • The effects of BW755C and other anti‐inflammatory drugs on eicosanoid concentrations and leukocyte accumulation in experimentally‐induced inflammation
    Salmon, Salmon; Simmons, Simmons; Moncada, Moncada
  • Prostaglandin E 2 , prostaglandin I 2 and the vascular changes of inflammation
    Williams, Williams
  • On the ability of prostaglandin E 1 and arachidonic acid to modulate experimentally‐induced oedema in the rat paw
    Lewis, Lewis; Nelson, Nelson; Sugrue, Sugrue
  • Leukotriene B 4 : a mediator of vascular permeability
    Bray, Bray; Cunningham, Cunningham; Ford‐Hutchinson, Ford‐Hutchinson
  • The inflammatory effects of hydroperoxy‐ and hydroxy‐acid products of arachidonate lipoxygenase in rabbit skin
    Higgs, Higgs; Salmon, Salmon; Spayne, Spayne
  • Prostaglandin E levels in third ventricular cerebrospinal fluid of rabbits during fever and changes in body temperature
    Bernheim, Bernheim; Gilbert, Gilbert; Stitt, Stitt

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