EICOSANOIDS AND INFLAMMATION K. I. WILLIAMS AND G. A. HIGGS* School o Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7A Y , U. K.; *Department of f Pharmacology, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U . K . Received 20 March 1988 Accepted 20 April 1988 KEY woms-Eicosanoids, prostaglandins,thromboxanes, leukotrienes, inflammation, anti-inflammatory drugs. most important source. The three main phospholipids into which AA is incorporated are phosphatiThe collective term eicosanoid is used to describe dyl choline, phosphatidyl ethanolamine and phosa range of widely differing chemical substances, e.g., phatidyl inositol. Groups of such phospholipid prostaglandins (PGs), thromboxanes (TXs), leuko- molecules in water exist together as a bilayer which trienes (LTs), and hydroxy acids (HETEs), which forms the basis of the cell membrane. Hence, all cell are produced by cells from polyunsaturated fatty membranes contain AA and have the potential acids, particularly arachidonic acid (AA), which capacity to produce eicosanoids when the AA is contain a 20-carbon atom chain. Twenty years ago, released from the phospholipid stores. In order for many of these substances were unknown, but the this to occur, the ester linkage joining AA to the ensuing period has seen a veritable
The Journal of Pathology – Wiley
Published: Oct 1, 1988
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