Efficacy of laryngectomy alone for treatment of locally advanced laryngeal cancer: A stage‐ and subsite‐specific survival analysis

Efficacy of laryngectomy alone for treatment of locally advanced laryngeal cancer: A stage‐ and... KeypointsPost operative radiotherapy (PORT) is commonly used in advanced stage larynx cancer.Patients with T3 primary tumors, N0 nodal disease, glottic subsite did not derive survival benefit when treated with PORT.Patients with T4a primary, N1 nodal disease, supraglottic subsite derived survival benefit with PORT.INTRODUCTIONApproximately 13 000 patients are diagnosed with laryngeal cancer each year, and 85‐95% of these tumours are squamous cell carcinomas (SCCs). The majority of patients with laryngeal cancer present with advanced stage disease, most of which is locally advanced. Advanced stage laryngeal cancer has a poor prognosis, carrying a five‐year survival rate of 39%‐60% independent of treatment modality.Advanced stage laryngeal cancer can be treated with surgery with or without adjuvant therapy or primary chemoradiation with similar overall long‐term survival outcomes. However, recent literature suggests that primary surgery may be more effective than chemoradiotherapy for specific subgroups of patients, such as those with T4a or supraglottic primaries, or N0 nodal disease. The gold‐standard surgical management for locally advanced disease is total laryngectomy and neck dissection although some T3 laryngeal tumours can be effectively managed with partial laryngectomy. The high efficacy of surgery for laryngeal cancer may be explained by the wide surgical margins inherent to total laryngectomy and the anatomic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Otolaryngology Wiley

Efficacy of laryngectomy alone for treatment of locally advanced laryngeal cancer: A stage‐ and subsite‐specific survival analysis

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 John Wiley & Sons Ltd
ISSN
1749-4478
eISSN
1749-4486
D.O.I.
10.1111/coa.13018
Publisher site
See Article on Publisher Site

Abstract

KeypointsPost operative radiotherapy (PORT) is commonly used in advanced stage larynx cancer.Patients with T3 primary tumors, N0 nodal disease, glottic subsite did not derive survival benefit when treated with PORT.Patients with T4a primary, N1 nodal disease, supraglottic subsite derived survival benefit with PORT.INTRODUCTIONApproximately 13 000 patients are diagnosed with laryngeal cancer each year, and 85‐95% of these tumours are squamous cell carcinomas (SCCs). The majority of patients with laryngeal cancer present with advanced stage disease, most of which is locally advanced. Advanced stage laryngeal cancer has a poor prognosis, carrying a five‐year survival rate of 39%‐60% independent of treatment modality.Advanced stage laryngeal cancer can be treated with surgery with or without adjuvant therapy or primary chemoradiation with similar overall long‐term survival outcomes. However, recent literature suggests that primary surgery may be more effective than chemoradiotherapy for specific subgroups of patients, such as those with T4a or supraglottic primaries, or N0 nodal disease. The gold‐standard surgical management for locally advanced disease is total laryngectomy and neck dissection although some T3 laryngeal tumours can be effectively managed with partial laryngectomy. The high efficacy of surgery for laryngeal cancer may be explained by the wide surgical margins inherent to total laryngectomy and the anatomic

Journal

Clinical OtolaryngologyWiley

Published: Jan 1, 2018

References

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