Keywords: haemophilia A, CMV retinitis, HIV, cottonwool spots. Efficacy of high-temperature dry heat in inactivating parvovirus The recent article by Flores et al. (Haemophilia, 1995; 1: 115) is misleading regarding the efficacy of high-temperaCure dry heat (80Â°C for 72 h or 100Â°C for 30 min) in inactivating parvovirus. It appears that their clinical surveillance took into account all concentrates, even though it is stated that 'Four had received clotting factor concentrates with two different inactivation methods.' In Spain, from where Flores et al. were reporting, concentrate inactivated by 80Â°C for 72 h + S-D is available. Was this used? We are not told about the patients who received only heat-inactivated (8OoC/72h) concentrate. Naturally, products inactivated solely by S-D without addition of high-temperature heat inactivation will transmit parvovirus. Furthermore, one must be cautious that there is true parvovirus infection rather than simply observing an immune response to heat inactivated virus. Lastly, inactivation by dry heat a t 100Â°C for 30 min and even longer exposure times must also be tried before making unwarranted conclusions. Finally, the presence of an immune response to parvovirus B19 does not demonstrate the presence of a true infection, but in the absence of other more accurate indicators - including the polymerase chain reaction [PCR] assay  - one must prudently consider the possibility of a true infection (the worst case scenario). G. FLORES, C. J. J. B. MONTORO,M. TUSELL, J. C. ALTISENT Haemophilia Unit, Ciudad Sanitaria Val1 d'Hebron, Barcelona, Spain JUAREZ,
Haemophilia – Wiley
Published: Jan 1, 1996
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