INTRODUCTIONContrast‐induced nephropathy (CIN), also known as contrast‐induced acute kidney injury (CIAKI), is a frequent complication after intravascular contrast media administration. It is defined as an increase in baseline serum creatinine (SCr) level by ≥ 25% or an absolute increase ≥ 44.2 umol/L within 48 or 72 hr after contrast media administration . The advanced development in the field of interventional cardiology resulted in an increasing number of CIN patients and CIN has become the third leading cause of hospital‐acquired acute kidney injury followed by surgical operation and nephrotoxic drug damage, accounting for 11% . However, the present guideline merely recommends the intravenous hydration, use of iso‐ or low‐osmolar contrast media, minimization of contrast volume to prevent the occurrence of CIN and none of other strategies were proved effective in preventing CIN . Therefore, effective strategies need to be explored to prevent the occurrence of CIN.Although the pathophysiological mechanisms of CIN are complex and uncertain, it may be associated with intense vasoconstriction mediated by endothelin, inhibition of nitric oxide‐mediated vasodilation, release of reactive oxygen species and direct toxic effects on tubular cells from contrast media, thus leading to ischemic injury of medulla outer area and the occurrence of CIN . In addition, the inadequate
Catheterization and Cardiovascular Interventions – Wiley
Published: Jan 1, 2018
Keywords: ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera