Efficacy and safety of flumazenil injection for the reversal of midazolam sedation after elective outpatient endoscopy

Efficacy and safety of flumazenil injection for the reversal of midazolam sedation after elective... INTRODUCTIONMidazolam is widely used nowadays for sedation during elective endoscopy. Its sedative effect is mediated by the γ‐aminobutyric acid neurotransmitter system. Midazolam binds to the benzodiazepine receptor ligand in the brain and its inhibitory function results in decreased muscle tone and reduced anxiety. It has a faster onset of action and a shorter duration of effect than other benzodiazepines.Flumazenil, a competitive benzodiazepine antagonist, can reverse the sedative and hypnotic effects of midazolam. It is well known that flumazenil has the effect of reversing benzodiazepine‐induced sedation and reducing recovery time. Therefore, the drug is frequently administered after endoscopy with midazolam sedation in clinical practice. Sometimes it is also used in routine procedures, especially if time, space and nursing resources are limited.The use of flumazenil to reverse midazolam sedation after endoscopy is generally believed to be safe. However, many of the studies were not randomized controlled trials (RCTs), or RCTs with a too small number of participants to reach significance and the sample size was not calculated. In addition, some studies have shown that the use of flumazenil can increase the risk of adverse effects in patients who are then admitted to the emergency ward with impaired consciousness due to benzodiazepine http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Digestive Diseases Wiley

Efficacy and safety of flumazenil injection for the reversal of midazolam sedation after elective outpatient endoscopy

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd
ISSN
1751-2972
eISSN
1751-2980
D.O.I.
10.1111/1751-2980.12579
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONMidazolam is widely used nowadays for sedation during elective endoscopy. Its sedative effect is mediated by the γ‐aminobutyric acid neurotransmitter system. Midazolam binds to the benzodiazepine receptor ligand in the brain and its inhibitory function results in decreased muscle tone and reduced anxiety. It has a faster onset of action and a shorter duration of effect than other benzodiazepines.Flumazenil, a competitive benzodiazepine antagonist, can reverse the sedative and hypnotic effects of midazolam. It is well known that flumazenil has the effect of reversing benzodiazepine‐induced sedation and reducing recovery time. Therefore, the drug is frequently administered after endoscopy with midazolam sedation in clinical practice. Sometimes it is also used in routine procedures, especially if time, space and nursing resources are limited.The use of flumazenil to reverse midazolam sedation after endoscopy is generally believed to be safe. However, many of the studies were not randomized controlled trials (RCTs), or RCTs with a too small number of participants to reach significance and the sample size was not calculated. In addition, some studies have shown that the use of flumazenil can increase the risk of adverse effects in patients who are then admitted to the emergency ward with impaired consciousness due to benzodiazepine

Journal

Journal of Digestive DiseasesWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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