EFFECTS ON PLASMA AND BRAIN TRYPTOPHAN IN THE RAT OF DRUGS AND HORMONES THAT INFLUENCE THE CONCENTRATION OF UNESTERIFIED FATTY ACID IN THE PLASMA

EFFECTS ON PLASMA AND BRAIN TRYPTOPHAN IN THE RAT OF DRUGS AND HORMONES THAT INFLUENCE THE... 1 The effects on tryptophan distribution and metabolism of drugs altering plasma unesterified fatty acid (UFA) concentration were investigated in the rat. 2 UFA and plasma free (i.e. ultrafilterable) tryptophan altered in the same direction. 3 Catecholamines and l‐DOPA increased both plasma UFA and free tryptophan. l‐DOPA also increased brain tryptophan and 5‐hydroxyindoleacetic acid (5‐HIAA) but decreased brain 5‐hydroxytryptamine (5‐HT). 4 Aminophylline increased plasma UFA and free tryptophan and also brain tryptophan, 5‐HT and 5‐HIAA. Food deprivation had qualitatively similar effects. 5 Insulin decreased plasma UFA and free tryptophan in both fed and food‐deprived rats. However, while in fed rats these changes were associated with small decreases of brain indoles, in food‐deprived animals small increases occurred. 6 Nicotinic acid had only small effects in fed rats but it opposed both the UFA and indole changes in food‐deprived animals. Total plasma tryptophan increased in nicotinic acid treated, food‐deprived rats. 7 There was a tendency towards inverse relations between changes of plasma free and total tryptophan. 8 The results suggest that drugs which influence plasma UFA through actions on cyclic AMP thereby alter the binding of tryptophan to plasma protein and that this leads to altered distribution and metabolism of tryptophan. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

EFFECTS ON PLASMA AND BRAIN TRYPTOPHAN IN THE RAT OF DRUGS AND HORMONES THAT INFLUENCE THE CONCENTRATION OF UNESTERIFIED FATTY ACID IN THE PLASMA

British Journal of Pharmacology, Volume 50 (2) – Feb 1, 1974

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Publisher
Wiley
Copyright
1974 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1111/j.1476-5381.1974.tb08562.x
Publisher site
See Article on Publisher Site

Abstract

1 The effects on tryptophan distribution and metabolism of drugs altering plasma unesterified fatty acid (UFA) concentration were investigated in the rat. 2 UFA and plasma free (i.e. ultrafilterable) tryptophan altered in the same direction. 3 Catecholamines and l‐DOPA increased both plasma UFA and free tryptophan. l‐DOPA also increased brain tryptophan and 5‐hydroxyindoleacetic acid (5‐HIAA) but decreased brain 5‐hydroxytryptamine (5‐HT). 4 Aminophylline increased plasma UFA and free tryptophan and also brain tryptophan, 5‐HT and 5‐HIAA. Food deprivation had qualitatively similar effects. 5 Insulin decreased plasma UFA and free tryptophan in both fed and food‐deprived rats. However, while in fed rats these changes were associated with small decreases of brain indoles, in food‐deprived animals small increases occurred. 6 Nicotinic acid had only small effects in fed rats but it opposed both the UFA and indole changes in food‐deprived animals. Total plasma tryptophan increased in nicotinic acid treated, food‐deprived rats. 7 There was a tendency towards inverse relations between changes of plasma free and total tryptophan. 8 The results suggest that drugs which influence plasma UFA through actions on cyclic AMP thereby alter the binding of tryptophan to plasma protein and that this leads to altered distribution and metabolism of tryptophan.

Journal

British Journal of PharmacologyWiley

Published: Feb 1, 1974

References

  • Effect of caffeine on central monoamine neurons
    Corrodi, Corrodi; Fuxe, Fuxe; Jonsson, Jonsson
  • Effects of immobilization and food deprivation on rat brain tryptophan metabolism
    Curzon, Curzon; Joseph, Joseph; Knott, Knott
  • Plasma and brain tryptophan changes in experimental acute hepatic failure
    Curzon, Curzon; Kantamaneni, Kantamaneni; Winch, Winch; Rojas‐Bueno, Rojas‐Bueno; Murray‐Lyon, Murray‐Lyon; Williams, Williams
  • Drugs influencing plasma and brain tryptophan
    Curzon, Curzon; Knott, Knott
  • Effects of food deprivation and immobilization on tryptophan and other amino acids in rat brain
    Knott, Knott; Joseph, Joseph; Curzon, Curzon
  • Stimulation of brain serotonin synthesis by dibutyryl‐cyclic AMP in rats
    Tagliamonte, Tagliamonte; Tagliamonte, Tagliamonte; Forn, Forn; Perez‐Cruet, Perez‐Cruet; Krishna, Krishna; Gessa, Gessa

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