Effects of training on exercise‐induced muscle damage and interleukin 6 production

Effects of training on exercise‐induced muscle damage and interleukin 6 production To address the question of whether the increased plasma concentration of interleukin 6 (IL‐6) following strenuous muscular work could be related to exercise‐induced muscle damage, 5 moderately active male volunteers underwent two isokinetic exercise sessions in the eccentric mode, separated by a period of 3 weeks during which the subjects underwent five training sessions. Before training, exercise was followed by severe muscle pain (delayed‐onset muscle soreness; DOMS), and by significant increases in plasma IL‐6 level and serum myoglobin concentration (SMb) (P < 0.001). After training, postexercise DOMS and SMb values were significantly lower than those measured before training. There was no significant difference between plasma IL‐6 levels measured at the same time points before and after training. We conclude that the hypothetical relationship between exercise‐induced muscle damage and increased postexercise levels of circulating IL‐6 is not substantiated by the present results. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 208–212, 1999 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Muscle and Nerve Wiley

Effects of training on exercise‐induced muscle damage and interleukin 6 production

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Publisher
Wiley
Copyright
Copyright © 1999 John Wiley & Sons, Inc.
ISSN
0148-639X
eISSN
1097-4598
DOI
10.1002/(SICI)1097-4598(199902)22:2<208::AID-MUS8>3.0.CO;2-B
Publisher site
See Article on Publisher Site

Abstract

To address the question of whether the increased plasma concentration of interleukin 6 (IL‐6) following strenuous muscular work could be related to exercise‐induced muscle damage, 5 moderately active male volunteers underwent two isokinetic exercise sessions in the eccentric mode, separated by a period of 3 weeks during which the subjects underwent five training sessions. Before training, exercise was followed by severe muscle pain (delayed‐onset muscle soreness; DOMS), and by significant increases in plasma IL‐6 level and serum myoglobin concentration (SMb) (P < 0.001). After training, postexercise DOMS and SMb values were significantly lower than those measured before training. There was no significant difference between plasma IL‐6 levels measured at the same time points before and after training. We conclude that the hypothetical relationship between exercise‐induced muscle damage and increased postexercise levels of circulating IL‐6 is not substantiated by the present results. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 208–212, 1999

Journal

Muscle and NerveWiley

Published: Feb 1, 1999

References

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