Effects of the 5‐HT 2B receptor agonist, BW 723C86, on three rat models of anxiety

Effects of the 5‐HT 2B receptor agonist, BW 723C86, on three rat models of anxiety 1 BW 723C86 (3 and 10 mg kg−1, s.c. 30 min pretest), a 5‐HT2B receptor agonist, increased total interaction, but not locomotion in a rat social interaction test, a profile consistent with anxiolysis. 2 The effect of BW 723C86 in the social interaction test is likely to be 5‐HT2B receptor‐mediated as it was prevented by pretreatment with the 5‐HT2C/2B receptor antagonist, SB 200646A, (1 and 2 mg kg−1, p.o., 1 h pretest) which did not affect basal levels of social interaction at the doses used. 3 An anxiolytic‐like action was also observed in the rat Geller‐Seifter conflict test, where BW 723C86 (0.5–50 mg kg−1, s.c. 30 min pretest) modestly, but significantly increased punished, but not unpublished responding. 4 In a rat 5 min elevated x‐maze test, BW 723C86 (1–10 mg kg−1, s.c.) had no significant effect. 5 The maximal anxiolytic‐like effect of BW 723C86 approached that of the benzodiazepine anxiolytic, chloradiazepoxide (5 mg kg−1, s.c. 30 min pretest) in the social interaction test, but was markedly less in the Geller‐Seifter test. The effect of BW 723C86 was also clearly less than chlordiazepoxide in the elevated x‐maze procedure where it had no significant effect. 6 In conclusion, BW 723C86 exerted an appreciable anxiolytic‐like profile in a rat social interaction test, but had a weaker effect in the Geller‐Siefter and was ineffective in the elevated x‐maze test used. These effects are likely to be 5‐HT2B receptor‐mediated. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Effects of the 5‐HT 2B receptor agonist, BW 723C86, on three rat models of anxiety

Loading next page...
 
/lp/wiley/effects-of-the-5-ht-2b-receptor-agonist-bw-723c86-on-three-rat-models-RJxBTinuLu
Publisher
Wiley
Copyright
1996 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1111/j.1476-5381.1996.tb15304.x
Publisher site
See Article on Publisher Site

Abstract

1 BW 723C86 (3 and 10 mg kg−1, s.c. 30 min pretest), a 5‐HT2B receptor agonist, increased total interaction, but not locomotion in a rat social interaction test, a profile consistent with anxiolysis. 2 The effect of BW 723C86 in the social interaction test is likely to be 5‐HT2B receptor‐mediated as it was prevented by pretreatment with the 5‐HT2C/2B receptor antagonist, SB 200646A, (1 and 2 mg kg−1, p.o., 1 h pretest) which did not affect basal levels of social interaction at the doses used. 3 An anxiolytic‐like action was also observed in the rat Geller‐Seifter conflict test, where BW 723C86 (0.5–50 mg kg−1, s.c. 30 min pretest) modestly, but significantly increased punished, but not unpublished responding. 4 In a rat 5 min elevated x‐maze test, BW 723C86 (1–10 mg kg−1, s.c.) had no significant effect. 5 The maximal anxiolytic‐like effect of BW 723C86 approached that of the benzodiazepine anxiolytic, chloradiazepoxide (5 mg kg−1, s.c. 30 min pretest) in the social interaction test, but was markedly less in the Geller‐Seifter test. The effect of BW 723C86 was also clearly less than chlordiazepoxide in the elevated x‐maze procedure where it had no significant effect. 6 In conclusion, BW 723C86 exerted an appreciable anxiolytic‐like profile in a rat social interaction test, but had a weaker effect in the Geller‐Siefter and was ineffective in the elevated x‐maze test used. These effects are likely to be 5‐HT2B receptor‐mediated.

Journal

British Journal of PharmacologyWiley

Published: Apr 1, 1996

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off