By Z. PELIKA.N & K. DE VRIES The purpose of this clinical experiment was to investigate the possibility of some drugs having protective effects when applied topically to the nasal mucosa before nasal provocation tests with allergen. By "protective effects" is meant the abilit)' of these drugs to prevent or to decrease the development of nasal mucosa changes (swelling, hypersecretion) caused by an antigen-antibody reaction. The antigen-antibody reaction was represented in our trial by nasal provocation tests using the challenge of a known allergen in a known dose. Two of these medicaments, i.e. an antihistaminic and an antiserotonic agent, were chosen as examples of antagonists to some mediators playing a possible role in an allergic reaction of the 1st type. Two others were representatives of sympathoniimetic and corticosteroid drugs. An alpha-sympathomimetic agent was chosen as a known topical decongestant of the nasal mucosa. Corticosteroids may suppress some types of antigenantibody reaction (7, 10) and one of their side-effects is topical decongestion. The "protective effects" of these drugs could be compared with the protective effects of Disodium cromoglycate (RynacromÂ®), demonstrated in our previous clinical experiments (16). 23 Acca Allcrgologica, 2v, 5 MATERIAL AND METHODS Drugs a) .ilpha-sympathomimetic drug: Xylometazoline
Allergy – Wiley
Published: Oct 1, 1974
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