Effects of MiR‐137 genetic risk score on brain volume and cortical measures in patients with schizophrenia and controls

Effects of MiR‐137 genetic risk score on brain volume and cortical measures in patients with... INTRODUCTIONGenome‐wide association studies (GWAS) of schizophrenia (SZ) have so far identified 108 regions of DNA encompassing ∼350 genes. A strongly polygenic model of SZ, where the overall influence of many genes of small effect combine to increase an individual's predisposition to SZ has been robustly supported (Purcell et al., ). No one “schizophrenia gene” of large effect has been identified, with the number of genes associated with the disorder increasing as GWAS sample size increases. This interplay of SZ risk genes is important to study, given the polygenic nature of the disorder. To characterize the phenotypic effects of multiple risk variants we and others have used polygenic risk scores calculated for gene sets based on either their involvement in a known biological pathway (Hargreaves et al., ), or based on evidence of their being regulated by target risk genes, for example, ZNF804A (Nicodemus et al., ); MIR137 (Cosgrove et al., ). In these studies, similar effects on cognitive function have been observed by studying either the risk variant individually or the gene network with which it interacts, although the network based analysis can sometimes explain a slightly higher percentage of variation (Cosgrove et al., ).Genetic variants within the gene http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Medical Genetics Wiley

Loading next page...
 
/lp/wiley/effects-of-mir-137-genetic-risk-score-on-brain-volume-and-cortical-dbp4OKzz5b
Publisher
Wiley
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
1552-4841
eISSN
1552-485X
D.O.I.
10.1002/ajmg.b.32620
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONGenome‐wide association studies (GWAS) of schizophrenia (SZ) have so far identified 108 regions of DNA encompassing ∼350 genes. A strongly polygenic model of SZ, where the overall influence of many genes of small effect combine to increase an individual's predisposition to SZ has been robustly supported (Purcell et al., ). No one “schizophrenia gene” of large effect has been identified, with the number of genes associated with the disorder increasing as GWAS sample size increases. This interplay of SZ risk genes is important to study, given the polygenic nature of the disorder. To characterize the phenotypic effects of multiple risk variants we and others have used polygenic risk scores calculated for gene sets based on either their involvement in a known biological pathway (Hargreaves et al., ), or based on evidence of their being regulated by target risk genes, for example, ZNF804A (Nicodemus et al., ); MIR137 (Cosgrove et al., ). In these studies, similar effects on cognitive function have been observed by studying either the risk variant individually or the gene network with which it interacts, although the network based analysis can sometimes explain a slightly higher percentage of variation (Cosgrove et al., ).Genetic variants within the gene

Journal

American Journal of Medical GeneticsWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off