Effects of intravenous dextrose infusion on muscle glycogen resynthesis after intense exercise

Effects of intravenous dextrose infusion on muscle glycogen resynthesis after intense exercise Summary Muscle glycogen resynthesis rates were studied in 6 Standardbred geldings that were exercised on a treadmill inclined at 10% slope to deplete muscle glycogen prior to treatments. Each horse completed 15 min at 50% V̇O2max, 15 min at 70% V̇O2max, 5 min at 90% V̇O2max then rested for 30 min. This was followed by 6, 1 min sprints at 100% V̇O2max with 5 min rest periods between sprints. Muscle biopsies were taken from the middle gluteal muscle at a depth of 8 cm using the same locations in each horse. Samples were taken before, at the end of exercise and 3, 6, 9, 12 and 24 h after treatment. Blood samples were collected before exercise, immediately after exercise, then every 60 min for 8 h after treatment. Thirty min after exercise each horse was treated with either 6 g/kg dextrose i.v. as a 20% solution in an isotonic electrolyte solution at a mean (± s.e.) infusion rate of 1.67 ± 0.05 1/h, or with a solution of equivalent volume of polyionic isotonic fluid (control) at the same infusion rate. Mean pre‐exercise and post infusion peak plasma glucose concentrations were 4.9 ± 0.1 and 28.6 ± 2.8 mmol/l and 4.7 ± 0.2 and 6.0 ± 0.5 mmol/l, for treatment and control respectively. Mean pre‐exercise and peak insulin concentrations were 0.007 ± 0.002 and 0.123 ± 0.022 μu/l and 0.006 ± 0.001 and 0.012 ± 0.002 μu/l, for treatment and control respectively. There were significant effects of both time and treatment for glucose and insulin (P<0.05). Mean rates of glycogen resynthesis for the first 12 h were 14.6 ± 2.6 mmol/kg/h and 2.6 ± 3.1 mmol/kg/h respectively for treatment and control and 7.0 ± 1.6 mmol/kg/h and 3.8 ± 1.2 mmol/kg/h for the first 24 h after treatments. The administration of large doses of dextrose i.v. after exercise increases the rate of muscle glycogen resynthesis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Equine Veterinary Journal Wiley

Effects of intravenous dextrose infusion on muscle glycogen resynthesis after intense exercise

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Publisher
Wiley
Copyright
© 1995 EVJ Ltd
ISSN
0425-1644
eISSN
2042-3306
D.O.I.
10.1111/j.2042-3306.1995.tb04918.x
Publisher site
See Article on Publisher Site

Abstract

Summary Muscle glycogen resynthesis rates were studied in 6 Standardbred geldings that were exercised on a treadmill inclined at 10% slope to deplete muscle glycogen prior to treatments. Each horse completed 15 min at 50% V̇O2max, 15 min at 70% V̇O2max, 5 min at 90% V̇O2max then rested for 30 min. This was followed by 6, 1 min sprints at 100% V̇O2max with 5 min rest periods between sprints. Muscle biopsies were taken from the middle gluteal muscle at a depth of 8 cm using the same locations in each horse. Samples were taken before, at the end of exercise and 3, 6, 9, 12 and 24 h after treatment. Blood samples were collected before exercise, immediately after exercise, then every 60 min for 8 h after treatment. Thirty min after exercise each horse was treated with either 6 g/kg dextrose i.v. as a 20% solution in an isotonic electrolyte solution at a mean (± s.e.) infusion rate of 1.67 ± 0.05 1/h, or with a solution of equivalent volume of polyionic isotonic fluid (control) at the same infusion rate. Mean pre‐exercise and post infusion peak plasma glucose concentrations were 4.9 ± 0.1 and 28.6 ± 2.8 mmol/l and 4.7 ± 0.2 and 6.0 ± 0.5 mmol/l, for treatment and control respectively. Mean pre‐exercise and peak insulin concentrations were 0.007 ± 0.002 and 0.123 ± 0.022 μu/l and 0.006 ± 0.001 and 0.012 ± 0.002 μu/l, for treatment and control respectively. There were significant effects of both time and treatment for glucose and insulin (P<0.05). Mean rates of glycogen resynthesis for the first 12 h were 14.6 ± 2.6 mmol/kg/h and 2.6 ± 3.1 mmol/kg/h respectively for treatment and control and 7.0 ± 1.6 mmol/kg/h and 3.8 ± 1.2 mmol/kg/h for the first 24 h after treatments. The administration of large doses of dextrose i.v. after exercise increases the rate of muscle glycogen resynthesis.

Journal

Equine Veterinary JournalWiley

Published: May 1, 1995

References

  • Effects of muscle glycogen content on glucose uptake following exercise
    Fell, Fell; Terblanche, Terblanche; Ivy, Ivy; Young, Young; Holloszy, Holloszy
  • Muscle glycogen synthesis after exercise: effect of time of carbohydrate ingestion
    Ivy, Ivy; Katz, Katz; Cutler, Cutler; Sherman, Sherman; Coyle, Coyle

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