Effects of HA‐966 on conflict, social interaction, and plus maze behaviors

Effects of HA‐966 on conflict, social interaction, and plus maze behaviors Antagonists at the N‐methyl‐D‐aspartate (NMDA) receptor share a number of properties, including anticonvulsant and anxiolytic‐like behaviors. In the Cook and Davidson conditioned conflict paradigm, the NMDA receptor complex antagonists HA‐966 (1 and 3 mg/kg), CPP (10 mg/kg), MK‐801 (0.03 mg/kg), and the benzodiazepine, diazepam (3 and 10 mg/kg) significantly disinhibited conflict responding. Likewise, in the social interaction test and elevated plus maze assay, two non‐conditioned paradigms predictive of anxiolytic activity, the NMDA antagonists HA‐966, CPP, and MK‐801, as well as diazepam, all significantly increased both social interaction time and open arm exploration time, respectively. In general, antagonism of the NMDA receptor complex results in anxiolytic behavior in rodents. Moreover, selective antagonism at the strychnine‐insensitive glycine modulatory site (HA‐966) may represent a new and novel class of compounds with potential therapeutic efficacy in anxiety. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Drug Development Research Wiley

Effects of HA‐966 on conflict, social interaction, and plus maze behaviors

Drug Development Research, Volume 24 (3) – Jan 1, 1991

Loading next page...
 
/lp/wiley/effects-of-ha-966-on-conflict-social-interaction-and-plus-maze-WZy11100vI
Publisher
Wiley
Copyright
Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company
ISSN
0272-4391
eISSN
1098-2299
DOI
10.1002/ddr.430240302
Publisher site
See Article on Publisher Site

Abstract

Antagonists at the N‐methyl‐D‐aspartate (NMDA) receptor share a number of properties, including anticonvulsant and anxiolytic‐like behaviors. In the Cook and Davidson conditioned conflict paradigm, the NMDA receptor complex antagonists HA‐966 (1 and 3 mg/kg), CPP (10 mg/kg), MK‐801 (0.03 mg/kg), and the benzodiazepine, diazepam (3 and 10 mg/kg) significantly disinhibited conflict responding. Likewise, in the social interaction test and elevated plus maze assay, two non‐conditioned paradigms predictive of anxiolytic activity, the NMDA antagonists HA‐966, CPP, and MK‐801, as well as diazepam, all significantly increased both social interaction time and open arm exploration time, respectively. In general, antagonism of the NMDA receptor complex results in anxiolytic behavior in rodents. Moreover, selective antagonism at the strychnine‐insensitive glycine modulatory site (HA‐966) may represent a new and novel class of compounds with potential therapeutic efficacy in anxiety.

Journal

Drug Development ResearchWiley

Published: Jan 1, 1991

Keywords: anxiety; conflict behavior; strychnine‐insensitive glycine antagonists

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off