Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta‐analysis of controlled clinical trials

Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a... Context: Exercise is widely perceived to be beneficial for glycemic control and weight loss in patients with type 2 diabetes. However, clinical trials on the effects of exercise in patients with type 2 diabetes have had small sample sizes and conflicting results. Objective: To systematically review and quantify the effect of exercise on glycosylated hemoglobin (HbA(1c)) and body mass in patients with type 2 diabetes. Data sources: Database searches of MEDLINE, EMBASE, Sport Discuss, Health Star, Dissertation Abstracts and the Cochrane Controlled Trials Register for the period up to and including December 2000. Additional data sources included bibliographies of textbooks and articles identified by the database searches. Study selection: We selected studies that evaluated the effects of exercise interventions (duration ≥ = 8 weeks) in adults with type 2 diabetes. Fourteen (11 randomized and three non‐randomized) controlled trials were included. Studies that included drug cointerventions were excluded. Data extraction: Two reviewers independently extracted baseline and post‐intervention means and SDs for the intervention and control groups. The characteristics of the exercise interventions and the methodological quality of the trials were also extracted. Data synthesis: Twelve aerobic training studies (mean (SD), 3.4 (0.9) times/week for 18 (15) weeks) and two resistance training studies (mean (SD), 10 (0.7) exercises, 2.5 (0.7) sets, 13 (0.7) repetitions, 2.5 (0.4) times/week for 15 (10) weeks) were included in the analyses. The weighted mean post‐intervention HbA(1c) was lower in the exercise groups compared with the control groups (7.65% vs 8.31%; weighted mean difference, 0.66%; P < 0.001). The difference in post‐intervention body mass between exercise groups and control groups was not significant (83.02 kg vs 82.48 kg; weighted mean difference, 0.54; P= 0.76). Conclusion: Exercise training reduces HbA(1c) by an amount that should decrease the risk of diabetic complications, but no significantly greater change in body mass was found when exercise groups were compared with control groups. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Scandinavian Journal of Medicine & Science in Sports Wiley

Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta‐analysis of controlled clinical trials

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Publisher
Wiley
Copyright
Copyright © 2002 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0905-7188
eISSN
1600-0838
D.O.I.
10.1034/j.1600-0838.2002.120111_3.x
Publisher site
See Article on Publisher Site

Abstract

Context: Exercise is widely perceived to be beneficial for glycemic control and weight loss in patients with type 2 diabetes. However, clinical trials on the effects of exercise in patients with type 2 diabetes have had small sample sizes and conflicting results. Objective: To systematically review and quantify the effect of exercise on glycosylated hemoglobin (HbA(1c)) and body mass in patients with type 2 diabetes. Data sources: Database searches of MEDLINE, EMBASE, Sport Discuss, Health Star, Dissertation Abstracts and the Cochrane Controlled Trials Register for the period up to and including December 2000. Additional data sources included bibliographies of textbooks and articles identified by the database searches. Study selection: We selected studies that evaluated the effects of exercise interventions (duration ≥ = 8 weeks) in adults with type 2 diabetes. Fourteen (11 randomized and three non‐randomized) controlled trials were included. Studies that included drug cointerventions were excluded. Data extraction: Two reviewers independently extracted baseline and post‐intervention means and SDs for the intervention and control groups. The characteristics of the exercise interventions and the methodological quality of the trials were also extracted. Data synthesis: Twelve aerobic training studies (mean (SD), 3.4 (0.9) times/week for 18 (15) weeks) and two resistance training studies (mean (SD), 10 (0.7) exercises, 2.5 (0.7) sets, 13 (0.7) repetitions, 2.5 (0.4) times/week for 15 (10) weeks) were included in the analyses. The weighted mean post‐intervention HbA(1c) was lower in the exercise groups compared with the control groups (7.65% vs 8.31%; weighted mean difference, 0.66%; P < 0.001). The difference in post‐intervention body mass between exercise groups and control groups was not significant (83.02 kg vs 82.48 kg; weighted mean difference, 0.54; P= 0.76). Conclusion: Exercise training reduces HbA(1c) by an amount that should decrease the risk of diabetic complications, but no significantly greater change in body mass was found when exercise groups were compared with control groups.

Journal

Scandinavian Journal of Medicine & Science in SportsWiley

Published: Feb 1, 2002

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