SHORT COMMUNICATION Effects of chronic treatment with neuroleptics on striatal acetylcholine concentration' (Receiwd 9 January 1976. 4ccepted 7 February 1976) DOPAMINE, released from nigrostriatal nerve endings, ing and temperature conditions for at least 1 week prior appears to have an inhibitory action on intrastriatal cho- to their use. All animals were killed at approximately the linergic neurons. Antipsychotic drugs, by blocking the same time of day (8-11 a.m.). striatal dopamine receptors, reduce the inhibitory action Chlorpromazine hydrochloride was dissolved in 0.9"" of dopamine on the striatal cholinergic neurons; this sodium chloride solution. Haloperidol and pimozide were results in increased cholinergic activity which leads to suspended in 1% sodium carboxymethylcellulose. Rats excessive release of acetylcholine from the striatum were injected subcutaneously, once a day, either for 5, 10 (STADLER ul., 1973) and a reduction in striatal acetylcho- or 20 days. Control rats received equal volumes of the et line concentration (SETHY& VANWOERT, 1974u.b). The vehicle. Rats were killed 30 min after the last injection excessive release of acetylcholine and reduction in its con- by a beam of microwave (Litton, Model 7C-50) radiation centration in the striatum may be related to antipsychotic focused o n the skull for 4 s.
Journal of Neurochemistry – Wiley
Published: Jul 1, 1976
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