Effects of chronic treatment with neuroleptics on striatal acetylcholine concentration

Effects of chronic treatment with neuroleptics on striatal acetylcholine concentration SHORT COMMUNICATION Effects of chronic treatment with neuroleptics on striatal acetylcholine concentration' (Receiwd 9 January 1976. 4ccepted 7 February 1976) DOPAMINE, released from nigrostriatal nerve endings, ing and temperature conditions for at least 1 week prior appears to have an inhibitory action on intrastriatal cho- to their use. All animals were killed at approximately the linergic neurons. Antipsychotic drugs, by blocking the same time of day (8-11 a.m.). striatal dopamine receptors, reduce the inhibitory action Chlorpromazine hydrochloride was dissolved in 0.9"" of dopamine on the striatal cholinergic neurons; this sodium chloride solution. Haloperidol and pimozide were results in increased cholinergic activity which leads to suspended in 1% sodium carboxymethylcellulose. Rats excessive release of acetylcholine from the striatum were injected subcutaneously, once a day, either for 5, 10 (STADLER ul., 1973) and a reduction in striatal acetylcho- or 20 days. Control rats received equal volumes of the et line concentration (SETHY& VANWOERT, 1974u.b). The vehicle. Rats were killed 30 min after the last injection excessive release of acetylcholine and reduction in its con- by a beam of microwave (Litton, Model 7C-50) radiation centration in the striatum may be related to antipsychotic focused o n the skull for 4 s. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

Effects of chronic treatment with neuroleptics on striatal acetylcholine concentration

Journal of Neurochemistry, Volume 27 (1) – Jul 1, 1976

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Publisher
Wiley
Copyright
Copyright © 1976 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
DOI
10.1111/j.1471-4159.1976.tb01592.x
Publisher site
See Article on Publisher Site

Abstract

SHORT COMMUNICATION Effects of chronic treatment with neuroleptics on striatal acetylcholine concentration' (Receiwd 9 January 1976. 4ccepted 7 February 1976) DOPAMINE, released from nigrostriatal nerve endings, ing and temperature conditions for at least 1 week prior appears to have an inhibitory action on intrastriatal cho- to their use. All animals were killed at approximately the linergic neurons. Antipsychotic drugs, by blocking the same time of day (8-11 a.m.). striatal dopamine receptors, reduce the inhibitory action Chlorpromazine hydrochloride was dissolved in 0.9"" of dopamine on the striatal cholinergic neurons; this sodium chloride solution. Haloperidol and pimozide were results in increased cholinergic activity which leads to suspended in 1% sodium carboxymethylcellulose. Rats excessive release of acetylcholine from the striatum were injected subcutaneously, once a day, either for 5, 10 (STADLER ul., 1973) and a reduction in striatal acetylcho- or 20 days. Control rats received equal volumes of the et line concentration (SETHY& VANWOERT, 1974u.b). The vehicle. Rats were killed 30 min after the last injection excessive release of acetylcholine and reduction in its con- by a beam of microwave (Litton, Model 7C-50) radiation centration in the striatum may be related to antipsychotic focused o n the skull for 4 s.

Journal

Journal of NeurochemistryWiley

Published: Jul 1, 1976

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