We wish to thank Merck Frosst Laboratories and Astra Chemicals Ltd. for their generous supply of drugs. This work has been supported by the Medical Research Council of Canada. DPpartement de Pharmacologie, Centre Hospitalier Universitaire, Universitb de Sherbrooke, Sherbrooke, Qukbec, Canada. November 4, 1971 REFERENCES DENIS GAGNON J. BOUCHER PIERRE BELISLE, & GAGNON, J. (1971). Br. J. Pharmac., 41, 361-366. S. D. GADDUM, H.(1953). Br. J . Pharmac. Chemother., 8, 321-326. J. GAGNON, J. (1970). Europ. J. Phnrmac., 10,297-300. D. GAGNON, J. & BELISLE, (1970). Ibid., 12, 303-309. D. S. GULATI, . GOKHALE, D., PARIKH, M., UDWADIA, P. & KRISHNAMURTY, R . 0 D., S. H. B. V. S. (1968). J. Pharmac. exp. Ther., 166, 35-43. * S-( -)-3-(3-t-Butylamino-2-hydroxypropoxy)-4-morpholino-l,2,5-thiadiazole maleate. Effects of caffeine on central monoamine neurons There is strong evidence that cyclic adenosine-3â,5â-monophosphate (cyclic AMP) plays an important regulating role in the function of the nervous system (see book edited by Greengard & Costa, 1970). The data so far support both a presynaptic and a postsynaptic action of cyclic AMP in synaptic transmission (Breekenridge & Bray, 1970; Hoffer, Siggins & Bloom, 1970). In line with this view it has been found that caffeine and theophylline, which are
Journal of Pharmacy and Pharmacology: An International Journal of Pharmaceutical Science – Wiley
Published: Feb 1, 1972
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