Effects of a cinnamon extract on plasma glucose, HbA 1c , and serum lipids in diabetes mellitus type 2

Effects of a cinnamon extract on plasma glucose, HbA 1c , and serum lipids in diabetes mellitus... Background According to previous studies, cinnamon may have a positive effect on the glycaemic control and the lipid profile in patients with diabetes mellitus type 2. The aim of this trial was to determine whether an aqueous cinnamon purified extract improves glycated haemoglobin A1c (HbA1c), fasting plasma glucose, total cholesterol, low‐density lipoprotein (LDL), high‐density lipoprotein (HDL) and triacylglycerol concentrations in patients with type 2 diabetes. Methods A total of 79 patients with diagnosed diabetes mellitus type 2 not on insulin therapy but treated with oral antidiabetics or diet were randomly assigned to take either a cinnamon extract or a placebo capsule three times a day for 4 months in a double‐blind study. The amount of aqueous cinnamon extract corresponded to 3 g of cinnamon powder per day. Results The mean absolute and percentage differences between the pre‐ and post‐intervention fasting plasma glucose level of the cinnamon and placebo groups were significantly different. There was a significantly higher reduction in the cinnamon group (10·3%) than in the placebo group (3·4%). No significant intragroup or intergroup differences were observed regarding HbA1c, lipid profiles or differences between the pre‐ and postintervention levels of these variables. The decrease in plasma glucose correlated significantly with the baseline concentrations, indicating that subjects with a higher initial plasma glucose level may benefit more from cinnamon intake. No adverse effects were observed. Conclusions The cinnamon extract seems to have a moderate effect in reducing fasting plasma glucose concentrations in diabetic patients with poor glycaemic control. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Investigation Wiley

Effects of a cinnamon extract on plasma glucose, HbA 1c , and serum lipids in diabetes mellitus type 2

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Publisher
Wiley
Copyright
Copyright © 2006 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0014-2972
eISSN
1365-2362
DOI
10.1111/j.1365-2362.2006.01629.x
pmid
16634838
Publisher site
See Article on Publisher Site

Abstract

Background According to previous studies, cinnamon may have a positive effect on the glycaemic control and the lipid profile in patients with diabetes mellitus type 2. The aim of this trial was to determine whether an aqueous cinnamon purified extract improves glycated haemoglobin A1c (HbA1c), fasting plasma glucose, total cholesterol, low‐density lipoprotein (LDL), high‐density lipoprotein (HDL) and triacylglycerol concentrations in patients with type 2 diabetes. Methods A total of 79 patients with diagnosed diabetes mellitus type 2 not on insulin therapy but treated with oral antidiabetics or diet were randomly assigned to take either a cinnamon extract or a placebo capsule three times a day for 4 months in a double‐blind study. The amount of aqueous cinnamon extract corresponded to 3 g of cinnamon powder per day. Results The mean absolute and percentage differences between the pre‐ and post‐intervention fasting plasma glucose level of the cinnamon and placebo groups were significantly different. There was a significantly higher reduction in the cinnamon group (10·3%) than in the placebo group (3·4%). No significant intragroup or intergroup differences were observed regarding HbA1c, lipid profiles or differences between the pre‐ and postintervention levels of these variables. The decrease in plasma glucose correlated significantly with the baseline concentrations, indicating that subjects with a higher initial plasma glucose level may benefit more from cinnamon intake. No adverse effects were observed. Conclusions The cinnamon extract seems to have a moderate effect in reducing fasting plasma glucose concentrations in diabetic patients with poor glycaemic control.

Journal

European Journal of Clinical InvestigationWiley

Published: May 1, 2006

References

  • Antidiabetic effect of Cinnamomum cassia and Cinnamomum zeylanicum in vivo and in vitro
    Verspohl, Verspohl; Bauer, Bauer; Neddermann, Neddermann
  • Dyslipidemia of the metabolic syndrome
    Ruotolo, Ruotolo; Howard, Howard
  • Lipoprotein abnormalities and their consequences for patients with type 2 diabetes
    Krentz, Krentz

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