Effect of the midazolam added with propofol‐based sedation in esophagogastroduodenoscopy: A randomized trial

Effect of the midazolam added with propofol‐based sedation in esophagogastroduodenoscopy: A... IntroductionSedation improves patient's satisfaction with endoscopy and also improves quality of the examination. Esophagogastroduodenoscopy (EGD) is a diagnostic technique widely used in the world, and it is more widely used as a screening apparatus of gastric cancer in the East. The use of sedation for EGD varies from country to country and even differs within the same country because of social, cultural, economic, and regulatory influences.Propofol is a short‐acting sedative‐hypnotic drug with a rapid onset of action and rapid recovery profile, and it is easy to use to maintain a proper sedation level. The onset of effect for propofol is 0.5 to 1 min and the duration of effect is 4 to 8 min. However, there are several adverse events, including respiratory depression, hypotension, and pain on injection. Hypotension is resulted from decreased cardiac output and systemic vascular resistance of propofol. With overdosing, respiratory depression generally precedes clinically significant hypotension. Pain on injection is reported by up to 30% of patients, especially when receiving an intravenous bolus of propofol. In addition, there is no existing pharmacologic antagonist recovering from the adverse effects.Midazolam is one of the benzodiazepines that have multiple pharmacologic effects and facilitating sedation for endoscopy. Benzodiazepines have anxiolytic, euphoriant, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Gastroenterology and Hepatology Wiley

Effect of the midazolam added with propofol‐based sedation in esophagogastroduodenoscopy: A randomized trial

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Publisher
Wiley
Copyright
© 2018 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd
ISSN
0815-9319
eISSN
1440-1746
D.O.I.
10.1111/jgh.14026
Publisher site
See Article on Publisher Site

Abstract

IntroductionSedation improves patient's satisfaction with endoscopy and also improves quality of the examination. Esophagogastroduodenoscopy (EGD) is a diagnostic technique widely used in the world, and it is more widely used as a screening apparatus of gastric cancer in the East. The use of sedation for EGD varies from country to country and even differs within the same country because of social, cultural, economic, and regulatory influences.Propofol is a short‐acting sedative‐hypnotic drug with a rapid onset of action and rapid recovery profile, and it is easy to use to maintain a proper sedation level. The onset of effect for propofol is 0.5 to 1 min and the duration of effect is 4 to 8 min. However, there are several adverse events, including respiratory depression, hypotension, and pain on injection. Hypotension is resulted from decreased cardiac output and systemic vascular resistance of propofol. With overdosing, respiratory depression generally precedes clinically significant hypotension. Pain on injection is reported by up to 30% of patients, especially when receiving an intravenous bolus of propofol. In addition, there is no existing pharmacologic antagonist recovering from the adverse effects.Midazolam is one of the benzodiazepines that have multiple pharmacologic effects and facilitating sedation for endoscopy. Benzodiazepines have anxiolytic, euphoriant,

Journal

Journal of Gastroenterology and HepatologyWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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