Effect of repeated skin administration on in vivo percutaneous absorption of drugs

Effect of repeated skin administration on in vivo percutaneous absorption of drugs Faculre de Pharmacie, Laboratoire de Pharmacologie, Unite de Dermopharmacologie, F 92290 Chatenay Malabry, France, *School of Medicine, Department of Dermatology, University of California, San Francisco, CA 94143, U.S.A. and **Faculte de Pharmacie, Laboratoire de Pharmacie Galenique et Biopharmacie, Universite de Picardie, F 80000 Amiens, France In clinical situations, topical dermatological therapeutic agents are administered on a repetitive basis. Data available on the effect of regular administration for topical drugs are scarce (Wester & Maibach, 1985). Our objective was to determine the in vivo percutaneous absorption of repeatedly applied substances. METHODS Three compounds were chosen: butylated hydroxytoluene (BHT) used as an antiviral agent against herpes, malathion organophosphate used for treatment of head lice, and benzoyl peroxide, a well-known antiaene agent. In vivo percutaneous absorption has been investigated after single or multiple applications to the guinea-pig retroauricular bald area (Zackheim & Langs, 1962). Guinea-pigs, individually housed in metabolic cages, were dosed daily for 15 days (malathion, neat product), 21 days (BHT, solution in LabrafiF'^ 10",,), or 25 days (benzoyl peroxide, solution in acetone or aqueous gel 10",,). Once a week, the animals received a radioactive dose of the drug labelled with 14-Carbon. On the other days, non-radioactive material was applied. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Dermatology Wiley

Effect of repeated skin administration on in vivo percutaneous absorption of drugs

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Publisher
Wiley
Copyright
Copyright © 1986 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0007-0963
eISSN
1365-2133
DOI
10.1111/j.1365-2133.1986.tb02109.x
Publisher site
See Article on Publisher Site

Abstract

Faculre de Pharmacie, Laboratoire de Pharmacologie, Unite de Dermopharmacologie, F 92290 Chatenay Malabry, France, *School of Medicine, Department of Dermatology, University of California, San Francisco, CA 94143, U.S.A. and **Faculte de Pharmacie, Laboratoire de Pharmacie Galenique et Biopharmacie, Universite de Picardie, F 80000 Amiens, France In clinical situations, topical dermatological therapeutic agents are administered on a repetitive basis. Data available on the effect of regular administration for topical drugs are scarce (Wester & Maibach, 1985). Our objective was to determine the in vivo percutaneous absorption of repeatedly applied substances. METHODS Three compounds were chosen: butylated hydroxytoluene (BHT) used as an antiviral agent against herpes, malathion organophosphate used for treatment of head lice, and benzoyl peroxide, a well-known antiaene agent. In vivo percutaneous absorption has been investigated after single or multiple applications to the guinea-pig retroauricular bald area (Zackheim & Langs, 1962). Guinea-pigs, individually housed in metabolic cages, were dosed daily for 15 days (malathion, neat product), 21 days (BHT, solution in LabrafiF'^ 10",,), or 25 days (benzoyl peroxide, solution in acetone or aqueous gel 10",,). Once a week, the animals received a radioactive dose of the drug labelled with 14-Carbon. On the other days, non-radioactive material was applied.

Journal

British Journal of DermatologyWiley

Published: Aug 1, 1986

References

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