Faculre de Pharmacie, Laboratoire de Pharmacologie, Unite de Dermopharmacologie, F 92290 Chatenay Malabry, France, *School of Medicine, Department of Dermatology, University of California, San Francisco, CA 94143, U.S.A. and **Faculte de Pharmacie, Laboratoire de Pharmacie Galenique et Biopharmacie, Universite de Picardie, F 80000 Amiens, France In clinical situations, topical dermatological therapeutic agents are administered on a repetitive basis. Data available on the effect of regular administration for topical drugs are scarce (Wester & Maibach, 1985). Our objective was to determine the in vivo percutaneous absorption of repeatedly applied substances. METHODS Three compounds were chosen: butylated hydroxytoluene (BHT) used as an antiviral agent against herpes, malathion organophosphate used for treatment of head lice, and benzoyl peroxide, a well-known antiaene agent. In vivo percutaneous absorption has been investigated after single or multiple applications to the guinea-pig retroauricular bald area (Zackheim & Langs, 1962). Guinea-pigs, individually housed in metabolic cages, were dosed daily for 15 days (malathion, neat product), 21 days (BHT, solution in LabrafiF'^ 10",,), or 25 days (benzoyl peroxide, solution in acetone or aqueous gel 10",,). Once a week, the animals received a radioactive dose of the drug labelled with 14-Carbon. On the other days, non-radioactive material was applied.
British Journal of Dermatology – Wiley
Published: Aug 1, 1986
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